ALG8 and IQGAP2

		ALG8	IQGAP2
Description		ALG8 alpha-1,3-glucosyltransferase	IQ motif containing GTPase activating protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Cytoplasm Cytosol Plasma Membrane Microvillus Cell Surface Actin Cytoskeleton Lamellipodium Filopodium Secretory Granule Membrane Extracellular Exosome
	Molecular Function	Alpha-1,3-mannosyltransferase Activity Dolichyl-phosphate-glucose-glycolipid Alpha-glucosyltransferase Activity Protein Binding Dolichyl Pyrophosphate Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity Dolichyl Pyrophosphate Glc1Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity	Actin Binding GTPase Inhibitor Activity Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Rho GTPase Binding Rac GTPase Binding Actin Filament Binding Arp2/3 Complex Binding
	Biological Process	Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Oligosaccharide-lipid Intermediate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Mannosylation	Signal Transduction Negative Regulation Of GTPase Activity Arp2/3 Complex-mediated Actin Nucleation Neutrophil Degranulation Thrombin-activated Receptor Signaling Pathway
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG8 causes ALG8-CDG (CDG-1h)	RHO GTPases activate IQGAPs Neutrophil degranulation
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Depression in smokers ( 30219690) Tourette syndrome ( 30818990)	Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Hearing impairment ( 20068591) High light scatter reticulocyte count ( 27863252) Late-onset Alzheimer's disease ( 27770636) Mean platelet volume ( 27863252) Phenylephrine infusion rate during anesthesia ( 31455332) Platelet count ( 27863252) Platelet distribution width ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Interacting Genes		8 interacting genes: CREB3 IQGAP2 LMNA NAE1 NARS2 RPS6KA5 RSF1 TMEM126B	6 interacting genes: ACTR2 ALG8 CALM1 CDC42 RAC1 RHOG
Entrez ID		79053	10788
HPRD ID		10480	09253
Ensembl ID		ENSG00000159063	ENSG00000145703
Uniprot IDs		A0A024R5K5 Q9BVK2	B7Z7U6 B7Z7X2 Q13576 Q59HA3
PDB IDs			3IEZ 4EZA 5CJP
Enriched GO Terms of Interacting Partners?
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