IL1R2 and IL1RAP

Number of citations of the paper that reports this interaction (PubMedID 9862719)
36

Data Source:
HPRD (in vivo)

		IL1R2	IL1RAP
Description		interleukin 1 receptor type 2	interleukin 1 receptor accessory protein
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Membrane Glutamatergic Synapse
	Molecular Function	Interleukin-1 Receptor Activity Interleukin-1, Type II, Blocking Receptor Activity Protein Binding Interleukin-1 Binding	Interleukin-33 Receptor Activity Interleukin-1 Receptor Activity Interleukin-1 Receptor Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	Immune Response Negative Regulation Of Protein Processing Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-1 Alpha Secretion Interleukin-1-mediated Signaling Pathway Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Interleukin-1-mediated Signaling Pathway	Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-5 Production Interleukin-33-mediated Signaling Pathway Interleukin-2 Biosynthetic Process Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Synapse Assembly Protein-containing Complex Assembly Interleukin-1-mediated Signaling Pathway Interleukin-4 Secretion Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling By Trans-synaptic Complex Synaptic Membrane Adhesion Regulation Of Presynapse Assembly Positive Regulation Of Interleukin-6 Secretion
Pathways		Interleukin-10 signaling Interleukin-1 signaling
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187 20062062) Asthma ( 31619474) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576 29875488) C-reactive protein levels ( 30388399) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Inflammatory bowel disease ( 28067908 23128233) Parkinson's disease ( 28892059) Ulcerative colitis ( 21297633)	Blood protein levels ( 30072576 29875488 28240269) Longitudinal change in brain amyloid plaque burden ( 26268530) Lung cancer ( 18385676) Waist circumference ( 20966902)
Interacting Genes		4 interacting genes: IL1A IL1B IL1RAP IL1RN	21 interacting genes: AP2M1 CCNI IL18R1 IL1A IL1B IL1R1 IL1R2 IRAK1 KPNA1 MARCHF8 MC4R MYD88 PIK3R1 PRKCI PRPF40A PTPRD RAC1 SIRPA STAT3 TICAM2 TOLLIP
Entrez ID		7850	3556
HPRD ID		00995	04021
Ensembl ID		ENSG00000115590	ENSG00000196083
Uniprot IDs		P27930	A8K6K4 Q9NPH3
PDB IDs		3O4O	3O4O 4DEP
Enriched GO Terms of Interacting Partners?
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