IL1RAP and CCNI

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		IL1RAP	CCNI
Description		interleukin 1 receptor accessory protein	cyclin I
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Membrane Glutamatergic Synapse	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm
	Molecular Function	Interleukin-33 Receptor Activity Interleukin-1 Receptor Activity Interleukin-1 Receptor Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-5 Production Interleukin-33-mediated Signaling Pathway Interleukin-2 Biosynthetic Process Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Synapse Assembly Protein-containing Complex Assembly Interleukin-1-mediated Signaling Pathway Interleukin-4 Secretion Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling By Trans-synaptic Complex Synaptic Membrane Adhesion Regulation Of Presynapse Assembly Positive Regulation Of Interleukin-6 Secretion	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Phosphorylation Spermatogenesis Mitotic Cell Cycle Phase Transition
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Longitudinal change in brain amyloid plaque burden ( 26268530) Lung cancer ( 18385676) Waist circumference ( 20966902)
Interacting Genes		21 interacting genes: AP2M1 CCNI IL18R1 IL1A IL1B IL1R1 IL1R2 IRAK1 KPNA1 MARCHF8 MC4R MYD88 PIK3R1 PRKCI PRPF40A PTPRD RAC1 SIRPA STAT3 TICAM2 TOLLIP	5 interacting genes: AKT1 CDC25A CEP63 IL1RAP KRT18
Entrez ID		3556	10983
HPRD ID		04021	16690
Ensembl ID		ENSG00000196083	ENSG00000118816
Uniprot IDs		A8K6K4 Q9NPH3	A0A024RDH0 Q14094
PDB IDs		3O4O 4DEP
Enriched GO Terms of Interacting Partners?
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