CSDE1 and DPYD

		CSDE1	DPYD
Description		cold shock domain containing E1	dihydropyrimidine dehydrogenase
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Plasma Membrane CRD-mediated MRNA Stability Complex	Cytoplasm Cytosol
	Molecular Function	RNA Binding Protein Binding	Uracil Binding Protein Binding Dihydropyrimidine Dehydrogenase (NADP+) Activity Protein Homodimerization Activity Metal Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Male Gonad Development Nuclear-transcribed MRNA Catabolic Process, No-go Decay	Purine Nucleobase Catabolic Process Pyrimidine Nucleobase Catabolic Process Thymine Catabolic Process Uracil Catabolic Process Thymidine Catabolic Process Beta-alanine Biosynthetic Process Pyrimidine Nucleoside Catabolic Process Oxidation-reduction Process
Pathways			Pyrimidine catabolism
Drugs			(5s)-5-Iododihydro-2,4(1h,3h)-Pyrimidinedione Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate 6-Carboxymethyluracil Flavin adenine dinucleotide Riboflavin Monophosphate Uracil Eniluracil 5-Iodouracil Gimeracil
Diseases			Dihydropyrimidine dehydrogenase deficiency
GWAS		Autism ( 24189344)	Adverse response to drug ( 30420678) Anthropometric traits (multi-trait analysis) ( 30166351) Anxiety/tension (special factor of neuroticism) ( 30867560) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index ( 25673413 29273807) Borderline personality disorder ( 28632202) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Extremely high intelligence ( 29520040) Face memory ( 31596458) Feeling nervous ( 29500382) Gastroesophageal reflux disease ( 31527586) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Irritable mood ( 29500382) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Methadone dose in opioid dependence ( 28115739) Platelet count ( 21507922) Regular attendance at a pub or social club ( 29970889) Schizophrenia ( 25056061 29483656 22688191 30285260 23974872) Sleep duration ( 30531941) Sleep duration (short sleep) ( 30846698) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		22 interacting genes: C11orf68 CDC7 CTBS DOK1 DPYD FAM9B GCKR GCNT1 GFI1 HID1 HNRNPD IGFBP5 KCNMB4 PABPC1 PCSK7 SH3GLB1 SLIT2 SNRPB2 STT3A SYNCRIP WFS1 WNK1	4 interacting genes: CLK1 CSDE1 GOPC LXN
Entrez ID		7812	1806
HPRD ID		15949	02036
Ensembl ID		ENSG00000009307	ENSG00000188641
Uniprot IDs		A0A024R0E2 A0A024R0K2 O75534	Q12882
PDB IDs		1WFQ 1X65 2YTV 2YTX 2YTY
Enriched GO Terms of Interacting Partners?
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