DPYD and LXN

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		DPYD	LXN
Description		dihydropyrimidine dehydrogenase	latexin
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Extracellular Space Cytoplasm
	Molecular Function	Uracil Binding Protein Binding Dihydropyrimidine Dehydrogenase (NADP+) Activity Protein Homodimerization Activity Metal Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Protein Binding Metalloendopeptidase Inhibitor Activity Heparin Binding
	Biological Process	Purine Nucleobase Catabolic Process Pyrimidine Nucleobase Catabolic Process Thymine Catabolic Process Uracil Catabolic Process Thymidine Catabolic Process Beta-alanine Biosynthetic Process Pyrimidine Nucleoside Catabolic Process Oxidation-reduction Process	Inflammatory Response Negative Regulation Of Endopeptidase Activity Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain
Pathways		Pyrimidine catabolism
Drugs		(5s)-5-Iododihydro-2,4(1h,3h)-Pyrimidinedione Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate 6-Carboxymethyluracil Flavin adenine dinucleotide Riboflavin Monophosphate Uracil Eniluracil 5-Iodouracil Gimeracil
Diseases		Dihydropyrimidine dehydrogenase deficiency
GWAS		Adverse response to drug ( 30420678) Anthropometric traits (multi-trait analysis) ( 30166351) Anxiety/tension (special factor of neuroticism) ( 30867560) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index ( 25673413 29273807) Borderline personality disorder ( 28632202) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Extremely high intelligence ( 29520040) Face memory ( 31596458) Feeling nervous ( 29500382) Gastroesophageal reflux disease ( 31527586) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Irritable mood ( 29500382) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Methadone dose in opioid dependence ( 28115739) Platelet count ( 21507922) Regular attendance at a pub or social club ( 29970889) Schizophrenia ( 25056061 29483656 22688191 30285260 23974872) Sleep duration ( 30531941) Sleep duration (short sleep) ( 30846698) Waist-to-hip ratio adjusted for BMI ( 28552196)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143)
Interacting Genes		4 interacting genes: CLK1 CSDE1 GOPC LXN	6 interacting genes: DPYD GSG1L MAGEA8 TMEM14A TRIM39 ZKSCAN4
Entrez ID		1806	56925
HPRD ID		02036	14327
Ensembl ID		ENSG00000188641	ENSG00000079257
Uniprot IDs		Q12882	Q9BS40
PDB IDs			2BO9
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?