SLC30A2 and SERPING1

Number of citations of the paper that reports this interaction (PubMedID 26871637)
108

Data Source:
BioGRID (two hybrid)

		SLC30A2	SERPING1
Description		solute carrier family 30 member 2	serpin family G member 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Late Endosome Plasma Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Zinc Ion Transmembrane Transporter Activity Protein Binding Identical Protein Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Response To Zinc Ion Regulation Of Sequestering Of Zinc Ion Positive Regulation Of Sequestering Of Zinc Ion Zinc Ion Transmembrane Transport	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Complement Activation, Classical Pathway Aging Blood Coagulation, Intrinsic Pathway Blood Circulation Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Fibrinolysis Innate Immune Response
Pathways		Zinc efflux and compartmentalization by the SLC30 family	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Regulation of Complement cascade
Drugs			C1-INH Copper
Diseases			Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency Hereditary angioedema
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576 29875488 28240269) Neuroticism ( 29255261) Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656)
Interacting Genes		11 interacting genes: ADAM33 CCL4 CCL4L2 CD99L2 CREB3 KASH5 LMNA LTA PVR SERPING1 TNFRSF12A	15 interacting genes: BAG6 C1R C1S ELANE ENO1 F2 MASP1 MASP2 NR4A1 PLAT PLG SELE SELP SLC30A2 SRPK2
Entrez ID		7780	710
HPRD ID		18057	06033
Ensembl ID		ENSG00000158014	ENSG00000149131
Uniprot IDs		Q9BRI3	E9KL26 P05155
PDB IDs			1M6Q 2OAY 5DU3 5DUQ
Enriched GO Terms of Interacting Partners?
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