TRIM25 and PLAAT4

Number of citations of the paper that reports this interaction (PubMedID 18948594)
95

Data Source:
BioGRID (pull down)

		TRIM25	PLAAT4
Description		tripartite motif containing 25	phospholipase A and acyltransferase 4
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol Cytoplasmic Stress Granule Nuclear Body	Cytosol Membrane Integral Component Of Membrane
	Molecular Function	RNA Binding Protein Binding Ligase Activity RIG-I Binding Cadherin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Phospholipase A2 Activity Protein Binding Phospholipase A1 Activity N-acyltransferase Activity Phosphatidylserine 1-acylhydrolase Activity 1-acyl-2-lysophosphatidylserine Acylhydrolase Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Viral Process Translesion Synthesis Ubiquitin-dependent ERAD Pathway Negative Regulation Of Type I Interferon Production Response To Vitamin D RIG-I Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Estrogen Innate Immune Response Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Release From Host Cell Cellular Response To Leukemia Inhibitory Factor	Phospholipid Metabolic Process Negative Regulation Of Cell Proliferation Lipid Catabolic Process Phosphatidylethanolamine Acyl-chain Remodeling Positive Regulation Of Keratinocyte Differentiation N-acylphosphatidylethanolamine Metabolic Process Positive Regulation Of Protein-glutamine Gamma-glutamyltransferase Activity
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Ovarian tumor domain proteases Interferon gamma signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling	Acyl chain remodelling of PE
Drugs
Diseases
GWAS		Height ( 18391951) Lean body mass ( 28552196)
Interacting Genes		36 interacting genes: AMFR APC ERCC2 ERG ESR1 GATA1 GRIK2 MAP3K13 MEIS2 MTA1 OTUB2 PAX2 PITX2 PLAAT4 RBCK1 RNF31 SFN STK11 STK38 TFG TRAF6 TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J2 UBE2L3 UBE2L6 UBE2N UBE2V1 USP15 USP39 ZC3HAV1 ZNF24	5 interacting genes: HRAS SGTA TGM1 TRIM25 UBE2I
Entrez ID		7706	5920
HPRD ID		02711	05479
Ensembl ID		ENSG00000121060	ENSG00000133321
Uniprot IDs		Q14258	Q9UL19
PDB IDs		4CFG 4LTB 5EYA 5FER 5NT1 5NT2 6FLM 6FLN	2LKT 2MY9
Enriched GO Terms of Interacting Partners?
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