PLAAT4 and TRIM25

Number of citations of the paper that reports this interaction (PubMedID 18948594)
95

Data Source:
BioGRID (pull down)

		PLAAT4	TRIM25
Description		phospholipase A and acyltransferase 4	tripartite motif containing 25
Image
GO Annotations	Cellular Component	Cytosol Membrane Integral Component Of Membrane	Nucleoplasm Cytosol Cytoplasmic Stress Granule Nuclear Body
	Molecular Function	Phospholipase A2 Activity Protein Binding Phospholipase A1 Activity N-acyltransferase Activity Phosphatidylserine 1-acylhydrolase Activity 1-acyl-2-lysophosphatidylserine Acylhydrolase Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)	RNA Binding Protein Binding Ligase Activity RIG-I Binding Cadherin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Phospholipid Metabolic Process Negative Regulation Of Cell Proliferation Lipid Catabolic Process Phosphatidylethanolamine Acyl-chain Remodeling Positive Regulation Of Keratinocyte Differentiation N-acylphosphatidylethanolamine Metabolic Process Positive Regulation Of Protein-glutamine Gamma-glutamyltransferase Activity	Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Viral Process Translesion Synthesis Ubiquitin-dependent ERAD Pathway Negative Regulation Of Type I Interferon Production Response To Vitamin D RIG-I Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Estrogen Innate Immune Response Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Release From Host Cell Cellular Response To Leukemia Inhibitory Factor
Pathways		Acyl chain remodelling of PE	ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Ovarian tumor domain proteases Interferon gamma signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS			Height ( 18391951) Lean body mass ( 28552196)
Interacting Genes		5 interacting genes: HRAS SGTA TGM1 TRIM25 UBE2I	36 interacting genes: AMFR APC ERCC2 ERG ESR1 GATA1 GRIK2 MAP3K13 MEIS2 MTA1 OTUB2 PAX2 PITX2 PLAAT4 RBCK1 RNF31 SFN STK11 STK38 TFG TRAF6 TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J2 UBE2L3 UBE2L6 UBE2N UBE2V1 USP15 USP39 ZC3HAV1 ZNF24
Entrez ID		5920	7706
HPRD ID		05479	02711
Ensembl ID		ENSG00000133321	ENSG00000121060
Uniprot IDs		Q9UL19	Q14258
PDB IDs		2LKT 2MY9	4CFG 4LTB 5EYA 5FER 5NT1 5NT2 6FLM 6FLN
Enriched GO Terms of Interacting Partners?
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