VASP and FRS3

Number of citations of the paper that reports this interaction (PubMedID 25814554)
22

Data Source:
BioGRID (two hybrid)

		VASP	FRS3
Description		vasodilator stimulated phosphoprotein	fibroblast growth factor receptor substrate 3
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Bicellular Tight Junction Focal Adhesion Actin Cytoskeleton Lamellipodium Membrane Filopodium Membrane Extracellular Exosome	Plasma Membrane
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding Cadherin Binding	Fibroblast Growth Factor Receptor Binding Protein Binding Identical Protein Binding
	Biological Process	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Cell Junction Assembly Protein Homotetramerization	MAPK Cascade Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway
Pathways		Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors Cell-extracellular matrix interactions	FRS-mediated FGFR1 signaling FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling RAF/MAP kinase cascade Activated NTRK2 signals through FRS2 and FRS3
Drugs
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717)	Menarche (age at onset) ( 25231870)
Interacting Genes		42 interacting genes: ABI1 ABI2 ABI3 ACTA1 ACTG1 APBB1 APBB1IP CEP43 DMRTB1 DNMBP ENAH ERMAP EVL FAT1 FRS3 FYB1 GSN IQGAP1 LPP NOL3 NR4A1 PFN1 PFN2 PLSCR1 PRKACA PRKG1 PRPF40A RAD51 RAPH1 SAT1 SCGB2A2 SPTA1 TES TRIM15 TRIM9 VCL WAS WASL WWP2 XIRP1 XPO6 ZYX	28 interacting genes: ADAMTSL4 BMPR2 CBY2 DDX5 FGFR1 GATA1 GRB14 GRB2 KARS1 MAPK1 MATK NOTCH2NLA NTRK1 NTRK2 NUMB PLSCR1 PRKCI PTPN11 RFX6 RND1 SH2B1 SOCS6 SPRY2 TCF4 TLE5 TNS1 TRIP6 VASP
Entrez ID		7408	10817
HPRD ID		03415	06373
Ensembl ID		ENSG00000125753	ENSG00000137218
Uniprot IDs		A0A024R0V4 P50552	A0A140VJJ7 O43559
PDB IDs		1EGX 1JNG 1USD 1USE 2PAV 2PBD 3CHW	2KUP 2KUQ 2YS5 2YT2
Enriched GO Terms of Interacting Partners?
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