FRS3 and MATK

Number of citations of the paper that reports this interaction (PubMedID 25814554)
22

Data Source:
BioGRID (two hybrid)

		FRS3	MATK
Description		fibroblast growth factor receptor substrate 3	megakaryocyte-associated tyrosine kinase
Image
GO Annotations	Cellular Component	Plasma Membrane	Cytosol Membrane
	Molecular Function	Fibroblast Growth Factor Receptor Binding Protein Binding Identical Protein Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	MAPK Cascade Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway	Protein Phosphorylation Positive Regulation Of Cell Proliferation Peptidyl-tyrosine Phosphorylation ERBB2 Signaling Pathway
Pathways		FRS-mediated FGFR1 signaling FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling RAF/MAP kinase cascade Activated NTRK2 signals through FRS2 and FRS3	Downregulation of ERBB2 signaling
Drugs
Diseases
GWAS		Menarche (age at onset) ( 25231870)	Obesity-related traits ( 23251661)
Interacting Genes		28 interacting genes: ADAMTSL4 BMPR2 CBY2 DDX5 FGFR1 GATA1 GRB14 GRB2 KARS1 MAPK1 MATK NOTCH2NLA NTRK1 NTRK2 NUMB PLSCR1 PRKCI PTPN11 RFX6 RND1 SH2B1 SOCS6 SPRY2 TCF4 TLE5 TNS1 TRIP6 VASP	20 interacting genes: AKT1 CACNA1A CD36 ERBB2 EWSR1 FRS3 HSPA5 HSPA9 ILK KIT LRRK1 LRRK2 LYN NTRK1 PTK2B PTPRD PXN SIRPA SMURF1 SRC
Entrez ID		10817	4145
HPRD ID		06373	02496
Ensembl ID		ENSG00000137218	ENSG00000007264
Uniprot IDs		A0A140VJJ7 O43559	F1T0G6 P42679
PDB IDs		2KUP 2KUQ 2YS5 2YT2	1JWO 1X6G 3US4
Enriched GO Terms of Interacting Partners?
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