C1QB and EDA2R

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		C1QB	EDA2R
Description		complement C1q B chain	ectodysplasin A2 receptor
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Complement Component C1 Complex Cell Synapse Collagen-containing Extracellular Matrix Blood Microparticle Postsynapse	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	Tumor Necrosis Factor-activated Receptor Activity Protein Binding Signaling Receptor Activity
	Biological Process	Complement Activation Complement Activation, Classical Pathway Regulation Of Complement Activation Innate Immune Response Inner Ear Development Synapse Pruning	Multicellular Organism Development Epidermis Development Ectodermal Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade	TNFs bind their physiological receptors
Drugs		Cetuximab Etanercept Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab tiuxetan Tositumomab Alemtuzumab Alefacept Efalizumab Natalizumab Palivizumab Daclizumab Bevacizumab Zinc
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS			Balding ( 26926045) Male-pattern baldness ( 27182965 22032556 28196072)
Interacting Genes		10 interacting genes: C1QA C1QC C1R DEFA1 EDA2R HRG IL32 MYOC PTX3 RELA	7 interacting genes: C1QB CASP8 CEBPE EDA FADD TRAF3 TRAF6
Entrez ID		713	60401
HPRD ID		00394	02230
Ensembl ID		ENSG00000173369	ENSG00000131080
Uniprot IDs		A0A024RAB9 P02746	B2RBZ9 B4DQY6 Q9HAV5
PDB IDs		1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ
Enriched GO Terms of Interacting Partners?
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