C1QB and MYOC

Number of citations of the paper that reports this interaction (PubMedID 16289162)
27

Data Source:
HPRD (two hybrid)

		C1QB	MYOC
Description		complement C1q B chain	myocilin
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Complement Component C1 Complex Cell Synapse Collagen-containing Extracellular Matrix Blood Microparticle Postsynapse	Extracellular Space Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Cytoplasmic Vesicle Node Of Ranvier Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding Metal Ion Binding
	Biological Process	Complement Activation Complement Activation, Classical Pathway Regulation Of Complement Activation Innate Immune Response Inner Ear Development Synapse Pruning	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway Via JNK Cascade ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs		Cetuximab Etanercept Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab tiuxetan Tositumomab Alemtuzumab Alefacept Efalizumab Natalizumab Palivizumab Daclizumab Bevacizumab Zinc
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency	Primary open angle glaucoma
GWAS			Cognitive decline rate in late mild cognitive impairment ( 26252872) Glaucoma ( 30104761) Intake of total sugars ( 31005972)
Interacting Genes		10 interacting genes: C1QA C1QC C1R DEFA1 EDA2R HRG IL32 MYOC PTX3 RELA	40 interacting genes: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 TGFBR1 TIMP1 TKT TNFRSF1A
Entrez ID		713	4653
HPRD ID		00394	03387
Ensembl ID		ENSG00000173369	ENSG00000034971
Uniprot IDs		A0A024RAB9 P02746	A0A0S2Z421 Q99972
PDB IDs		1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ	4WXQ 4WXS 4WXU 6OU0 6OU1 6OU2 6OU3 6PKD 6PKE 6PKF
Enriched GO Terms of Interacting Partners?
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