TLE2 and LEF1

Number of citations of the paper that reports this interaction (PubMedID 15768032)
203

Data Source:
BioGRID (pull down)

		TLE2	LEF1
Description		TLE family member 2, transcriptional corepressor	lymphoid enhancer binding factor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Transcription Factor Complex Focal Adhesion Nuclear Body	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Protein-DNA Complex Beta-catenin-TCF Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding DNA Binding, Bending Estrogen Receptor Activity Estrogen Receptor Binding Enhancer Binding Histone Binding Histone Deacetylase Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Gamma-catenin Binding Armadillo Repeat Domain Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Blood Vessel Morphogenesis Osteoblast Differentiation Somitogenesis Epithelial To Mesenchymal Transition Sprouting Angiogenesis Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Wnt Signaling Pathway, Calcium Modulating Pathway Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Regulation Of Striated Muscle Tissue Development Dentate Gyrus Development Forebrain Radial Glial Cell Differentiation Forebrain Neuroblast Division Formation Of Radial Glial Scaffolds Regulation Of Cell-cell Adhesion Regulation Of Wnt Signaling Pathway Neutrophil Differentiation Positive Regulation Of Cell Growth Embryonic Limb Morphogenesis Positive Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of Granulocyte Differentiation Mammary Gland Development Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-4 Production Negative Regulation Of Interleukin-5 Production T Cell Receptor V(D)J Recombination B Cell Proliferation Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of DNA Binding Steroid Hormone Mediated Signaling Pathway Tongue Development Positive Regulation By Host Of Viral Transcription Histone H3 Acetylation Histone H4 Acetylation T-helper 1 Cell Differentiation Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Alpha-beta T Cell Differentiation Eye Pigmentation Paraxial Mesoderm Formation Sensory Perception Of Taste Anatomical Structure Regression Canonical Wnt Signaling Pathway Face Morphogenesis Cell Chemotaxis Apoptotic Process Involved In Morphogenesis Chorio-allantoic Fusion Trachea Gland Development Secondary Palate Development Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-4 Positive Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Apoptotic Process In Bone Marrow Odontoblast Differentiation Negative Regulation Of Estrogen Receptor Binding Apoptotic Process Involved In Blood Vessel Morphogenesis Beta-catenin-TCF Complex Assembly
Pathways		Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes	Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes Repression of WNT target genes Transcriptional Regulation by VENTX RUNX3 regulates WNT signaling Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis
Drugs			Etacrynic acid
Diseases
GWAS			Airflow obstruction ( 22837378) Blond vs. brown/black hair color ( 30531825) Chronic lymphocytic leukemia ( 28165464 26956414 23770605) Diastolic blood pressure ( 27841878) Medication use (calcium channel blockers) ( 31015401) Metabolic traits ( 19060910) Multiple sclerosis ( 31604244) Systemic lupus erythematosus ( 22291604) Systolic blood pressure ( 27841878 30578418) Tooth agenesis (mandibular second premolars) ( 29364747)
Interacting Genes		16 interacting genes: BARHL1 EMX2 FOXA3 H3-3A HES1 HMGB1 LEF1 MSX1 MSX2 PAX9 PRDM1 RUNX1 TLE1 TLX3 UTY VENTX	25 interacting genes: ALX4 ALYREF CDX1 CTNNB1 DPYSL2 EP300 KPNA1 KPNA2 MITF NLK NOTCH1 PIAS4 PITX2 RAP1GDS1 RUNX2 SMAD1 SMAD2 SMAD3 SMAD4 SUMO2 TLE1 TLE2 TRA UBTF ZBTB3
Entrez ID		7089	51176
HPRD ID		03025	01075
Ensembl ID		ENSG00000065717	ENSG00000138795
Uniprot IDs		K7EMK7 Q04725	Q659G9 Q9UJU2
PDB IDs
Enriched GO Terms of Interacting Partners?
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