LEF1 and ALX4

Number of citations of the paper that reports this interaction (PubMedID 11696550)
13

Data Source:
HPRD (in vitro)

		LEF1	ALX4
Description		lymphoid enhancer binding factor 1	ALX homeobox 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Protein-DNA Complex Beta-catenin-TCF Complex	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding DNA Binding, Bending Estrogen Receptor Activity Estrogen Receptor Binding Enhancer Binding Histone Binding Histone Deacetylase Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Gamma-catenin Binding Armadillo Repeat Domain Binding C2H2 Zinc Finger Domain Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding HMG Box Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Blood Vessel Morphogenesis Osteoblast Differentiation Somitogenesis Epithelial To Mesenchymal Transition Sprouting Angiogenesis Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Wnt Signaling Pathway, Calcium Modulating Pathway Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Regulation Of Striated Muscle Tissue Development Dentate Gyrus Development Forebrain Radial Glial Cell Differentiation Forebrain Neuroblast Division Formation Of Radial Glial Scaffolds Regulation Of Cell-cell Adhesion Regulation Of Wnt Signaling Pathway Neutrophil Differentiation Positive Regulation Of Cell Growth Embryonic Limb Morphogenesis Positive Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of Granulocyte Differentiation Mammary Gland Development Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-4 Production Negative Regulation Of Interleukin-5 Production T Cell Receptor V(D)J Recombination B Cell Proliferation Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of DNA Binding Steroid Hormone Mediated Signaling Pathway Tongue Development Positive Regulation By Host Of Viral Transcription Histone H3 Acetylation Histone H4 Acetylation T-helper 1 Cell Differentiation Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Alpha-beta T Cell Differentiation Eye Pigmentation Paraxial Mesoderm Formation Sensory Perception Of Taste Anatomical Structure Regression Canonical Wnt Signaling Pathway Face Morphogenesis Cell Chemotaxis Apoptotic Process Involved In Morphogenesis Chorio-allantoic Fusion Trachea Gland Development Secondary Palate Development Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-4 Positive Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Apoptotic Process In Bone Marrow Odontoblast Differentiation Negative Regulation Of Estrogen Receptor Binding Apoptotic Process Involved In Blood Vessel Morphogenesis Beta-catenin-TCF Complex Assembly	Skeletal System Development Hair Follicle Development Muscle Organ Development Post-embryonic Development Anterior/posterior Pattern Specification Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Embryonic Skeletal System Morphogenesis Roof Of Mouth Development
Pathways		Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes Repression of WNT target genes Transcriptional Regulation by VENTX RUNX3 regulates WNT signaling Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis
Drugs		Etacrynic acid
Diseases			Frontonasal dysplasia Enlarged parietal foramina/cranium bifidum
GWAS		Airflow obstruction ( 22837378) Blond vs. brown/black hair color ( 30531825) Chronic lymphocytic leukemia ( 28165464 26956414 23770605) Diastolic blood pressure ( 27841878) Medication use (calcium channel blockers) ( 31015401) Metabolic traits ( 19060910) Multiple sclerosis ( 31604244) Systemic lupus erythematosus ( 22291604) Systolic blood pressure ( 27841878 30578418) Tooth agenesis (mandibular second premolars) ( 29364747)	Blood pressure measurement (high sodium intervention) ( 24165912) Cadmium levels ( 26025379) Excessive hairiness ( 29895819) Gout ( 22179738) Male-pattern baldness ( 29146897 27182965) Monobrow ( 27182965) Response to antidepressants in depression ( 29998114) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)
Interacting Genes		25 interacting genes: ALX4 ALYREF CDX1 CTNNB1 DPYSL2 EP300 KPNA1 KPNA2 MITF NLK NOTCH1 PIAS4 PITX2 RAP1GDS1 RUNX2 SMAD1 SMAD2 SMAD3 SMAD4 SUMO2 TLE1 TLE2 TRA UBTF ZBTB3	12 interacting genes: ALX1 CEBPE EMX1 FOXA3 GATA4 HOXA3 HOXB13 HOXB6 HOXD3 LEF1 SOX10 SOX2
Entrez ID		51176	60529
HPRD ID		01075	05661
Ensembl ID		ENSG00000138795	ENSG00000052850
Uniprot IDs		Q659G9 Q9UJU2	Q9H161
PDB IDs			2M0C
Enriched GO Terms of Interacting Partners?
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