TH and CDK11B

Number of citations of the paper that reports this interaction (PubMedID 14675149)
5

Data Source:
HPRD (two hybrid, in vitro)

		TH	CDK11B
Description		tyrosine hydroxylase	cyclin dependent kinase 11B
Image			No pdb structure
GO Annotations	Cellular Component	Cell Nucleus Cytoplasm Mitochondrion Smooth Endoplasmic Reticulum Cytosol Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Axon Dendrite Cytoplasmic Vesicle Melanosome Membrane Neuron Projection Terminal Bouton Perikaryon	Nucleus Cytoplasm
	Molecular Function	Tyrosine 3-monooxygenase Activity Protein Binding Ferrous Iron Binding Ferric Iron Binding Amino Acid Binding Oxygen Binding Enzyme Binding Protein Domain Specific Binding Tetrahydrobiopterin Binding Dopamine Binding	RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Response To Hypoxia Synaptic Transmission, Dopaminergic Response To Amphetamine Heart Morphogenesis Dopamine Biosynthetic Process From Tyrosine Fatty Acid Metabolic Process Sphingolipid Metabolic Process Heart Development Visual Perception Sensory Perception Of Sound Learning Memory Mating Behavior Locomotory Behavior Regulation Of Heart Contraction Response To Water Deprivation Response To Light Stimulus Response To Herbicide Response To Salt Stress Anatomical Structure Morphogenesis Animal Organ Morphogenesis Response To Zinc Ion Multicellular Organism Aging Response To Activity Aminergic Neurotransmitter Loading Into Synaptic Vesicle Glycoside Metabolic Process Phthalate Metabolic Process Cerebral Cortex Development Response To Nutrient Levels Response To Estradiol Response To Lipopolysaccharide Isoquinoline Alkaloid Metabolic Process Social Behavior Response To Isolation Stress Response To Immobilization Stress Neurotransmitter Biosynthetic Process Terpene Metabolic Process Dopamine Biosynthetic Process Epinephrine Biosynthetic Process Norepinephrine Biosynthetic Process Catecholamine Biosynthetic Process Eye Photoreceptor Cell Development Circadian Sleep/wake Cycle Eating Behavior Response To Peptide Hormone Pigmentation Response To Ethanol Response To Ether Response To Pyrethroid Embryonic Camera-type Eye Morphogenesis Response To Corticosterone Response To Electrical Stimulus Phytoalexin Metabolic Process Oxidation-reduction Process Cellular Response To Manganese Ion Cellular Response To Alkaloid Cellular Response To Nicotine Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus	Mitotic Cell Cycle Regulation Of Cell Growth Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Regulation Of Mitotic Cell Cycle Regulation Of Gene Expression Regulation Of MRNA Processing
Pathways		Catecholamine biosynthesis	Recruitment of mitotic centrosome proteins and complexes
Drugs		L-Phenylalanine L-Tyrosine Sapropterin Metyrosine 3-Tyrosine
Diseases		Primary torsion dystonia (PTD)
GWAS		Celiac disease ( 23936387) Height ( 31562340) Prostate cancer ( 19767753) Prostate cancer (early onset) ( 24740154) Prostate cancer (SNP x SNP interaction) ( 22219177) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 31324766 25102180)	Body mass index ( 26426971)
Interacting Genes		12 interacting genes: CAMK2G CDK11B CSNK2A1 MAPK1 MAPK3 MAPKAPK2 PRKACA RPS6KA5 SNCA TYSND1 YWHAB YWHAZ	24 interacting genes: AP2M1 CASP1 CASP3 CASP8 CCND3 CCNL2 CHEK2 EIF3F KAT7 MSN PAK1 PIN1 PPIL3 RANBP9 RPS27A TCEA2 TH TPPP URM1 YWHAB YWHAE YWHAG YWHAQ YWHAZ
Entrez ID		7054	984
HPRD ID		01865	08909
Ensembl ID		ENSG00000180176	ENSG00000248333
Uniprot IDs		P07101 P78428	B4DII1 P21127
PDB IDs		2XSN 4J6S
Enriched GO Terms of Interacting Partners?
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