TEAD4 and MYH7

Number of citations of the paper that reports this interaction (PubMedID 12861002)
28

Data Source:
HPRD (two hybrid, in vitro)

		TEAD4	MYH7
Description		TEA domain transcription factor 4	myosin heavy chain 7
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex	Stress Fiber Muscle Myosin Complex Myosin Complex Myofibril Sarcomere Z Disc Myosin Filament
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	Microfilament Motor Activity Protein Binding Calmodulin Binding ATP Binding ATPase Activity Actin-dependent ATPase Activity Actin Filament Binding
	Biological Process	Skeletal System Development Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Muscle Organ Development Hippo Signaling Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development	Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Skeletal Muscle Contraction Muscle Contraction Striated Muscle Contraction Adult Heart Development Regulation Of The Force Of Skeletal Muscle Contraction Transition Between Fast And Slow Fiber Cardiac Muscle Hypertrophy In Response To Stress Muscle Filament Sliding Regulation Of Slow-twitch Skeletal Muscle Fiber Contraction ATP Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription
Drugs			4-[4-(2,5-DIOXO-PYRROLIDIN-1-YL)-PHENYLAMINO]-4-HYDROXY-BUTYRIC ACID
Diseases			Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Hypertrophic cardiomyopathy (HCM) Myosin storage myopathy (MSM); Hyaline body myopathy Scapuloperoneal myopathy (SPM) Dilated cardiomyopathy (DCM)
GWAS		Narcolepsy with cataplexy ( 23496005)	Atrial fibrillation ( 30061737 29892015) Resting heart rate ( 27798624 20639392)
Interacting Genes		29 interacting genes: CCDC172 CCDC85B CCNDBP1 CEP55 CEP70 CTBP1 EXOC3-AS1 FBXO7 GOLGA2 HOMEZ KIAA0753 KRT40 KRTAP10-3 LZTS2 MDFI MTUS2 MYH7 PDE4DIP PFKM PNMA1 RABGEF1 RUNDC3A SSX2IP TRAF1 TRIM27 VGLL1 VPS52 WWTR1 YAP1	5 interacting genes: DISC1 KXD1 TEAD1 TEAD3 TEAD4
Entrez ID		7004	4625
HPRD ID		03421	01175
Ensembl ID		ENSG00000197905	ENSG00000092054
Uniprot IDs		Q15561	P12883
PDB IDs		5GZB 5NO6 5OAQ 6GE3 6GE4 6GE5 6GE6 6GEC 6GEE 6GEG 6GEI 6GEK 6HIK 6Q2X 6Q36 6SEN 6SEO	1IK2 2FXM 2FXO 3DTP 4DB1 4P7H 4PA0 4XA1 4XA3 4XA4 4XA6 5CHX 5CJ0 5CJ1 5CJ4 5TBY 5WJ7 5WJB 5WLQ 5WLZ 5WME
Enriched GO Terms of Interacting Partners?
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