TCF12 and ADAM10

		TCF12	ADAM10
Description		transcription factor 12	ADAM metallopeptidase domain 10
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Nuclear Speck Intracellular Membrane-bounded Organelle RNA Polymerase II Transcription Factor Complex	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Lumen Golgi Apparatus Golgi-associated Vesicle Trans-Golgi Network Plasma Membrane Adherens Junction Focal Adhesion Synaptic Vesicle Cell Surface Postsynaptic Density Membrane Integral Component Of Membrane Clathrin-coated Vesicle Axon Specific Granule Membrane Neuronal Cell Body Dendritic Spine Intracellular Membrane-bounded Organelle Postsynaptic Membrane Pore Complex Extracellular Exosome Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum Synaptic Membrane Tetraspanin-enriched Microdomain Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Enhancer Binding CAMP Response Element Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Transcription Regulatory Region DNA Binding SMAD Binding Protein Heterodimerization Activity E-box Binding HMG Box Domain Binding	Endopeptidase Activity Metalloendopeptidase Activity Signaling Receptor Binding Integrin Binding Protein Binding Metallopeptidase Activity SH3 Domain Binding Protein Kinase Binding Protein Homodimerization Activity Metal Ion Binding Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
	Biological Process	Regulation Of Transcription By RNA Polymerase II Immune Response Muscle Organ Development Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Hematopoietic Stem Cell Differentiation	In Utero Embryonic Development Protein Phosphorylation Membrane Protein Ectodomain Proteolysis Negative Regulation Of Cell Adhesion Notch Signaling Pathway Integrin-mediated Signaling Pathway Cell-cell Signaling Spermatogenesis Positive Regulation Of Cell Proliferation Regulation Of Notch Signaling Pathway Positive Regulation Of T Cell Chemotaxis Protein Processing Extracellular Matrix Disassembly Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Amyloid-beta Formation Adherens Junction Organization Response To Tumor Necrosis Factor Notch Receptor Processing, Ligand-dependent Monocyte Activation Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process Pore Complex Assembly PMA-inducible Membrane Protein Ectodomain Proteolysis Constitutive Protein Ectodomain Proteolysis Regulation Of Dendritic Spine Morphogenesis Cochlea Development Response To Antineoplastic Agent Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynapse Organization Regulation Of Vasculature Development Toxin Transport
Pathways		Myogenesis Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs NGF-stimulated transcription NGF-stimulated transcription	Collagen degradation Degradation of the extracellular matrix Signaling by EGFR Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Neutrophil degranulation Post-translational protein phosphorylation NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Amyloid fiber formation
Drugs			XL784
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Alcohol consumption (drinks per week) ( 30643258) Body mass index ( 28892062) Glaucoma (primary open-angle) ( 29891935) Male-pattern baldness ( 28196072) Mean platelet volume ( 27863252) Type 2 diabetes ( 30297969)	Alzheimer's disease (late onset) ( 30820047) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Chronotype ( 30696823) Diffusing capacity of carbon monoxide ( 30694715) Family history of Alzheimer's disease ( 30617256) Metabolite levels ( 23823483) Schizophrenia ( 30285260)
Interacting Genes		59 interacting genes: ACTB ADAM10 ARMC8 ASCL4 BCL2L10 BMERB1 BMF C1orf109 CDKN2C CFAP206 CRCP CREBBP DGCR6 EDRF1 EP300 FRMD6 HAND1 HOPX ID1 ID2 ID3 LYSMD1 MAPK6 MAPKBP1 MLLT6 MORN4 MSC MYF6 NAGK OLIG3 OSGIN1 PRSS23 PSMA1 PTF1A QARS1 RNASEL RSL24D1 RUNX1T1 SCG3 SLC12A1 SLC24A1 SOX10 SOX8 SPG21 SPTBN5 SRI STAT5A STK16 TAF4 TAL2 TBP TCF23 TCF3 TRIM72 TSNAX TWIST2 VPS28 YKT6 ZNF688	8 interacting genes: AXL DLL1 EFNA1 EFNA2 EPHA3 SH3D19 TCF12 TGFA
Entrez ID		6938	102
HPRD ID		02725	03723
Ensembl ID		ENSG00000140262	ENSG00000137845
Uniprot IDs		A0A024R5T1 A0A024R5Z0 F5GY10 Q99081	A0A024R5U5 O14672
PDB IDs		2KNH 4JOL	1M1I 6BDZ 6BE6
Enriched GO Terms of Interacting Partners?
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