TARBP2 and KCNIP3

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		TARBP2	KCNIP3
Description		TARBP2 subunit of RISC loading complex	potassium voltage-gated channel interacting protein 3
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol RISC Complex Nuclear Body Perinuclear Region Of Cytoplasm RISC-loading Complex	Nucleus Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Dendrite Protein-DNA Complex Axon Terminus
	Molecular Function	Double-stranded RNA Binding Protein Binding Enzyme Binding SiRNA Binding MiRNA Binding Pre-mRNA Binding Identical Protein Binding Protein Homodimerization Activity Protein N-terminus Binding Pre-miRNA Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Transcription Corepressor Activity Voltage-gated Ion Channel Activity Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Ion Channel Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Spermatid Development Single Fertilization MiRNA Metabolic Process Production Of SiRNA Involved In RNA Interference Targeting Of MRNA For Destruction Involved In RNA Interference Pre-miRNA Processing SiRNA Loading Onto RISC Involved In RNA Interference Production Of MiRNAs Involved In Gene Silencing By MiRNA Multicellular Organism Growth MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Skeletal Muscle Tissue Regeneration Positive Regulation Of Viral Genome Replication Positive Regulation Of Translation Regulation Of Viral Transcription Negative Regulation Of Defense Response To Virus By Host Positive Regulation Of Muscle Cell Differentiation Neural Precursor Cell Proliferation Regulation Of Production Of SiRNA Involved In RNA Interference Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Intracellular Protein Transport Apoptotic Process Signal Transduction Cardiac Conduction Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport
Pathways		MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis	Phase 1 - inactivation of fast Na+ channels
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		22 interacting genes: AGO2 APP DICER1 EIF2AK2 HDHD2 HSPB1 IKBKG KCNIP3 MAPK8IP2 MED21 NEDD4L NEUROG1 NF2 NUDT18 PRKRA RBM14 TCEANC TGIF2 TOP1 TRAF4 VAV2 ZNF346	18 interacting genes: CALM2 CASP3 CD177 CLN3 CREB1 CREM CTBP2 GRK2 GRK6 IGF1R IGLV3-25 IL6ST MAVS PCBD2 PPP3CA PSEN1 PSEN2 TARBP2
Entrez ID		6895	30818
HPRD ID		05446	05232
Ensembl ID		ENSG00000139546	ENSG00000115041
Uniprot IDs		A0A024RB49 Q15633	A0A024RE22 Q9Y2W7
PDB IDs		2CPN 3ADL 3LLH 4WYQ 5N8L 5N8M 5ZAK 5ZAL 5ZAM	2E6W
Enriched GO Terms of Interacting Partners?
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