TACC1 and LSM7

Number of citations of the paper that reports this interaction (PubMedID 12165861)
17

Data Source:
BioGRID (pull down, two hybrid)
HPRD (in vitro, two hybrid, in vivo)

		TACC1	LSM7
Description		transforming acidic coiled-coil containing protein 1	LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Organizing Center Cytosol Membrane Midbody	Nucleus Nucleoplasm U6 SnRNP U12-type Spliceosomal Complex Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome Spliceosomal Tri-snRNP Complex Lsm2-8 Complex Lsm1-7-Pat1 Complex Ribonucleoprotein Complex
	Molecular Function	Protein Binding Nuclear Receptor Binding Estrogen Receptor Binding Glucocorticoid Receptor Binding Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding	Protein Binding U6 SnRNA Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Cell Proliferation Cerebral Cortex Development Cell Division Positive Regulation Of Nuclear Receptor Transcription Coactivator Activity	MRNA Splicing, Via Spliceosome Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Pathways			mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Chronic mountain sickness ( 31417607) Midgestational circulating levels of PBDEs ( 28235828)	Parkinson's disease ( 28892059)
Interacting Genes		15 interacting genes: AURKA AURKB BTRC HTT ITSN2 KAT2A KDM1A LSM7 MEMO1 SH2D4A SNRPG STX5 TDRD7 THAP12 YEATS4	24 interacting genes: ARF6 DDIT4L EPHA2 EXOSC6 EXOSC8 LDB1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM8 MYH13 NPY1R PFKM RAB29 RASSF5 SART3 SMN1 SNRPD3 SNRPF TACC1 ZSCAN26
Entrez ID		6867	51690
HPRD ID		10391	06287
Ensembl ID		ENSG00000147526	ENSG00000130332
Uniprot IDs		E7EVI4 O75410 Q5HYH0	Q9UK45
PDB IDs			3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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