STX1A and SLC6A3

Number of citations of the paper that reports this interaction (PubMedID 18617632)
67

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)
HPRD (two hybrid, in vitro, in vivo)

		STX1A	SLC6A3
Description		syntaxin 1A	solute carrier family 6 member 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Endomembrane System Postsynaptic Density Integral Component Of Membrane Cell Junction Secretory Granule Integral Component Of Synaptic Vesicle Membrane Axon SNARE Complex Nuclear Membrane Actomyosin Presynaptic Membrane Neuron Projection Presynaptic Active Zone Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Glutamatergic Synapse Integral Component Of Presynaptic Membrane	Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane Flotillin Complex Axon Neuronal Cell Body Membrane Presynaptic Membrane Neuron Projection Neuronal Cell Body Membrane Raft Dopaminergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Calcium Channel Inhibitor Activity Chloride Channel Inhibitor Activity Kinase Binding Protein Domain Specific Binding Myosin Head/neck Binding Identical Protein Binding ATP-dependent Protein Binding Ion Channel Binding Protein-containing Complex Binding Protein N-terminus Binding Calcium-dependent Protein Binding	Protease Binding Signaling Receptor Binding Neurotransmitter:sodium Symporter Activity Dopamine:sodium Symporter Activity Norepinephrine:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Dopamine Binding Protein-containing Complex Binding Metal Ion Binding Protein N-terminus Binding Protein Phosphatase 2A Binding
	Biological Process	Positive Regulation Of Neurotransmitter Secretion Intracellular Protein Transport Exocytosis Vesicle Fusion Neurotransmitter Secretion Response To Gravity Positive Regulation Of Norepinephrine Secretion Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Protein Sumoylation Calcium Ion Regulated Exocytosis Cytokine-mediated Signaling Pathway Insulin Secretion Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Secretion By Cell Positive Regulation Of Catecholamine Secretion SNARE Complex Assembly Positive Regulation Of Calcium Ion-dependent Exocytosis Vesicle Docking Synaptic Vesicle Endocytosis Regulation Of Insulin Secretion Protein Localization To Membrane Positive Regulation Of Excitatory Postsynaptic Potential	Transport Aging Lactation Sensory Perception Of Smell Locomotory Behavior Response To Iron Ion Monoamine Transport Dopamine Transport Norepinephrine Transport Adenohypophysis Development Response To Nicotine Positive Regulation Of Multicellular Organism Growth Regulation Of Dopamine Metabolic Process Neurotransmitter Biosynthetic Process Response To Cocaine Dopamine Biosynthetic Process Dopamine Catabolic Process Response To Ethanol Dopamine Uptake Involved In Synaptic Transmission Response To CAMP Norepinephrine Uptake Transmembrane Transport Prepulse Inhibition Dopamine Uptake
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Insulin processing Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type C (BoNT/C) LGI-ADAM interactions Neurexins and neuroligins GABA synthesis, release, reuptake and degradation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Dopamine clearance from the synaptic cleft Na+/Cl- dependent neurotransmitter transporters Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)
Drugs			Amphetamine Phentermine Benzatropine Venlafaxine Atomoxetine Mirtazapine Loxapine Methylphenidate Pethidine Imipramine Duloxetine Amoxapine Mazindol Procaine Trimipramine Modafinil Phenmetrazine Pseudoephedrine Benzphetamine Cocaine Diethylpropion Dopamine Sertraline Sibutramine Chlorphenamine Diphenylpyraline Nefazodone Bupropion Chloroprocaine Escitalopram Lisdexamfetamine Ephedra MMDA Midomafetamine Fencamfamine 4-Methoxyamphetamine Dextroamphetamine Methamphetamine Vanoxerine Nomifensine Altropane Mianserin Armodafinil Dexmethylphenidate Dasotraline
Diseases
GWAS			Pancreatic cancer ( 25086665)
Interacting Genes		60 interacting genes: ABCC9 APBA1 ATP4B ATP6V1B1 CACNA1D CCSER2 CDK5 CFTR CPLX1 CSNK2A1 CSNK2A2 DAPK1 KCNB1 NAPA NAPB NSF PSMA3 RAB27A RIMS1 SCNN1A SCNN1B SCNN1G SDCBP SEC22B SEPTIN2 SEPTIN5 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A9 SNAP23 SNAP25 SNAP29 SNPH STX8 STXBP1 STXBP2 STXBP5 STXBP6 SUMO1P1 SYT1 SYT4 SYT7 SYTL4 TRDMT1 TXLNA TXLNB UNC13B VAMP1 VAMP2 VAMP5 VAMP7 VAMP8 VAPB VIM VPS11 VPS16 VPS18	9 interacting genes: DRD2 MTNR1A NEDD4 PICK1 RACK1 SNCA SNTA1 STX1A TGFB1I1
Entrez ID		6804	6531
HPRD ID		01721	00543
Ensembl ID		ENSG00000106089	ENSG00000142319
Uniprot IDs		Q16623 Q75ME0	Q01959
PDB IDs
Enriched GO Terms of Interacting Partners?
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