STX1A and SLC6A1

Number of citations of the paper that reports this interaction (PubMedID 11017172)
42

Data Source:
HPRD (in vivo, in vitro)

		STX1A	SLC6A1
Description		syntaxin 1A	solute carrier family 6 member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Endomembrane System Postsynaptic Density Integral Component Of Membrane Cell Junction Secretory Granule Integral Component Of Synaptic Vesicle Membrane Axon SNARE Complex Nuclear Membrane Actomyosin Presynaptic Membrane Neuron Projection Presynaptic Active Zone Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Glutamatergic Synapse Integral Component Of Presynaptic Membrane	Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Cell Junction Axon Neuron Projection GABA-ergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Calcium Channel Inhibitor Activity Chloride Channel Inhibitor Activity Kinase Binding Protein Domain Specific Binding Myosin Head/neck Binding Identical Protein Binding ATP-dependent Protein Binding Ion Channel Binding Protein-containing Complex Binding Protein N-terminus Binding Calcium-dependent Protein Binding	Gamma-aminobutyric Acid:sodium Symporter Activity Protein Binding Neurotransmitter Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Neurotransmitter Secretion Intracellular Protein Transport Exocytosis Vesicle Fusion Neurotransmitter Secretion Response To Gravity Positive Regulation Of Norepinephrine Secretion Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Protein Sumoylation Calcium Ion Regulated Exocytosis Cytokine-mediated Signaling Pathway Insulin Secretion Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Secretion By Cell Positive Regulation Of Catecholamine Secretion SNARE Complex Assembly Positive Regulation Of Calcium Ion-dependent Exocytosis Vesicle Docking Synaptic Vesicle Endocytosis Regulation Of Insulin Secretion Protein Localization To Membrane Positive Regulation Of Excitatory Postsynaptic Potential	Transport Chemical Synaptic Transmission Learning Response To Toxic Substance Response To Sucrose Response To Lead Ion Positive Regulation Of Gamma-aminobutyric Acid Secretion Response To Purine-containing Compound Taurine Transport Negative Regulation Of Synaptic Transmission, GABAergic Response To Estradiol Response To Cocaine Response To Calcium Ion Gamma-aminobutyric Acid Import Transmembrane Transport Neurotransmitter Reuptake
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Insulin processing Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type C (BoNT/C) LGI-ADAM interactions Neurexins and neuroligins GABA synthesis, release, reuptake and degradation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Na+/Cl- dependent neurotransmitter transporters Reuptake of GABA
Drugs			Tiagabine Guvacine
Diseases
GWAS			Body fat percentage ( 31752434) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Loneliness (linear analysis) ( 27629369) Longitudinal alcohol consumption ( 26081443) Response to Vitamin E supplementation ( 22437554)
Interacting Genes		60 interacting genes: ABCC9 APBA1 ATP4B ATP6V1B1 CACNA1D CCSER2 CDK5 CFTR CPLX1 CSNK2A1 CSNK2A2 DAPK1 KCNB1 NAPA NAPB NSF PSMA3 RAB27A RIMS1 SCNN1A SCNN1B SCNN1G SDCBP SEC22B SEPTIN2 SEPTIN5 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A9 SNAP23 SNAP25 SNAP29 SNPH STX8 STXBP1 STXBP2 STXBP5 STXBP6 SUMO1P1 SYT1 SYT4 SYT7 SYTL4 TRDMT1 TXLNA TXLNB UNC13B VAMP1 VAMP2 VAMP5 VAMP7 VAMP8 VAPB VIM VPS11 VPS16 VPS18	1 interacting genes: STX1A
Entrez ID		6804	6529
HPRD ID		01721	00664
Ensembl ID		ENSG00000106089	ENSG00000157103
Uniprot IDs		Q16623 Q75ME0	A0A2R8Y4I3 B7Z3C5 P30531
PDB IDs
Enriched GO Terms of Interacting Partners?
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