DST and APC

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		DST	APC
Description		dystonin	APC regulator of WNT signaling pathway
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GO Annotations	Cellular Component	Basement Membrane Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Intermediate Filament Focal Adhesion Cell Cortex Basal Plasma Membrane Microtubule Cytoskeleton Membrane Integral Component Of Membrane Z Disc Hemidesmosome Cell Leading Edge Cytoplasmic Vesicle H Zone Microtubule Plus-end Axon Cytoplasm	Kinetochore Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Microtubule Cytoplasmic Microtubule Plasma Membrane Adherens Junction Bicellular Tight Junction Lateral Plasma Membrane Catenin Complex Lamellipodium Beta-catenin Destruction Complex Ruffle Membrane Perinuclear Region Of Cytoplasm Wnt Signalosome
	Molecular Function	Actin Binding Integrin Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Microtubule Binding Protein C-terminus Binding Microtubule Plus-end Binding	Protein Binding Beta-catenin Binding Microtubule Binding Protein Kinase Regulator Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Gamma-catenin Binding Cadherin Binding Microtubule Plus-end Binding Dynein Complex Binding
	Biological Process	Cytoskeleton Organization Cell Adhesion Integrin-mediated Signaling Pathway Retrograde Axonal Transport Response To Wounding Maintenance Of Cell Polarity Cytoplasmic Microtubule Organization Hemidesmosome Assembly Wound Healing Intermediate Filament Cytoskeleton Organization Cell Motility	Mitotic Cytokinesis Cell Fate Specification Cellular Response To DNA Damage Stimulus Negative Regulation Of Microtubule Depolymerization Cell Cycle Arrest Mitotic Spindle Assembly Checkpoint Cell Adhesion Pattern Specification Process Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Cell Death Wnt Signaling Pathway Cell Migration Protein Deubiquitination Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Regulation Of Microtubule-based Process Positive Regulation Of Apoptotic Process Regulation Of Cell Differentiation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Attachment Of Spindle Microtubules To Kinetochore Protein-containing Complex Assembly Bicellular Tight Junction Assembly Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Protein Localization To Centrosome Beta-catenin Destruction Complex Assembly Beta-catenin Destruction Complex Disassembly
Pathways		Type I hemidesmosome assembly	Apoptotic cleavage of cellular proteins Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Deactivation of the beta-catenin transactivating complex Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants are not K63 polyubiquitinated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Ovarian tumor domain proteases
Drugs
Diseases			Familial adenomatous polyposis Esophageal cancer Gastric cancer Cancer of the anal canal Gallbladder cancer
GWAS		Alzheimer disease and age of onset ( 26830138) Attention function in attention deficit hyperactive disorder ( 26174813) Cerebrospinal fluid clusterin levels ( 26545630) Daytime sleep phenotypes ( 27126917) Heel bone mineral density ( 30598549) Menarche (age at onset) ( 25231870) Small cell lung carcinoma ( 28604730)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Body mass index ( 29273807) Colorectal cancer or advanced adenoma ( 30510241) Heel bone mineral density ( 30598549) Reaction time ( 29844566) Total body bone mineral density ( 29304378)
Interacting Genes		27 interacting genes: APC CALM1 CDC5L CELSR3 CEP63 COL17A1 DCTN1 DISC1 DTNBP1 ECPAS ERBIN EXOC1 ITGB4 ITSN2 KIAA1549 KRT14 KRT5 MAPK6 MTNR1B NFYC PAK2 PRKAB2 PRKD2 SH3BP5 SMAD9 TNIK TRAF3IP1	123 interacting genes: ACTN1 ADGRL1 AGFG1 AGR3 ANKRD17 ANXA7 AP2B1 ARHGEF4 ASAP2 AXIN1 AXIN2 BUB1 BUB1B C4A CASC3 CCL5 CGNL1 COG4 COG5 CREBBP CSNK1A1 CSNK1E CTBP1 CTNNA1 CTNNB1 CYP17A1 CYTH2 DIRAS3 DKK3 DLG3 DLGAP1 DST EPAS1 ERBIN EXPH5 FAM214A FBXO30 FHOD1 FLNA GIGYF2 GOLGA2 GSK3B HGS HNRNPM HOXC6 HSPA5 HTRA2 IL24 ING5 IQGAP1 JUP KIAA1328 KIF5B KIFAP3 KRT13 KRT14 KRT15 KRT17 KRT19 KRT23 KRT5 LAMA3 LAMA4 MACF1 MAPRE1 MAPRE2 MBD5 MCM3AP MKRN1 MT-ND4 MUC1 MYH10 MYH11 MYO6 NAT2 NAV1 NAV2 NAV3 NCKAP5 NCKAP5L NEB NOSTRIN NUP153 NUP214 NUP42 NUP54 NUP58 NUP98 PDLIM2 PNISR POM121 POM121C PPP1R13B PPP2CA PPP2R5A PRKACA PSMD1 PTPN13 RANBP9 RBM4B RP1 RPS27 SCRIB SEC31A SETDB1 SIAH1 SMC3 SNRNP200 SPECC1L SPTBN1 SPTBN2 ST14 SYNE1 TAF1 TFAP2A TFF1 TPR TRIM21 TRIM25 TUBA4A XPO1 YWHAQ ZNF106
Entrez ID		667	324
HPRD ID		00222	01439
Ensembl ID		ENSG00000151914	ENSG00000134982
Uniprot IDs		B4DGY0 B4DSS9 E9PHM6 F6QMI7 F8W9J4 Q03001 Q6P0N6	P25054 Q4LE70
PDB IDs		3GJO	1DEB 1EMU 1JPP 1M5I 1T08 1TH1 1V18 2RQU 3AU3 3NMW 3NMX 3NMZ 3QHE 3RL7 3RL8 3T7U 4G69 4YJE 4YJL 4YK6 5B6G 5IZ6 5IZ8 5IZ9 5IZA 5Z8H
Enriched GO Terms of Interacting Partners?
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