SOX2 and XPO1

Number of citations of the paper that reports this interaction (PubMedID 19591226)
48

Data Source:
BioGRID (pull down)

		SOX2	XPO1
Description		SRY-box transcription factor 2	exportin 1
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Nuclear Transcription Factor Complex	Kinetochore Nucleus Nuclear Envelope Annulate Lamellae Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle Host Cell Ribonucleoprotein Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding MiRNA Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	RNA Binding Nuclear Export Signal Receptor Activity Protein Binding Ran GTPase Binding Protein Domain Specific Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Eye Development Endodermal Cell Fate Specification Chromatin Organization Regulation Of Transcription, DNA-templated Cell Cycle Arrest Response To Wounding Anatomical Structure Morphogenesis Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Glial Cell Fate Commitment Pituitary Gland Development Adenohypophysis Development Positive Regulation Of Cell-cell Adhesion Cell Differentiation Forebrain Development Somatic Stem Cell Population Maintenance Tissue Regeneration Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAPK Cascade Cell Fate Commitment Positive Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development Negative Regulation Of Epithelial Cell Proliferation Response To Growth Factor Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Population Maintenance	Ribosomal Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Negative Regulation Of Transcription By RNA Polymerase II Protein Export From Nucleus Nucleocytoplasmic Transport Regulation Of Centrosome Duplication Viral Process Protein Localization To Nucleus Regulation Of Protein Catabolic Process Ribosome Biogenesis Response To Drug Regulation Of MRNA Stability Regulation Of Protein Export From Nucleus MRNA Transport Intracellular Transport Of Virus
Pathways		POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Deactivation of the beta-catenin transactivating complex Transcriptional regulation of pluripotent stem cells Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by MECP2	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA NEP/NS2 Interacts with the Cellular Export Machinery Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deactivation of the beta-catenin transactivating complex HuR (ELAVL1) binds and stabilizes mRNA RHO GTPases Activate Formins MAPK6/MAPK4 signaling Mitotic Prometaphase Cyclin A/B1/B2 associated events during G2/M transition Estrogen-dependent nuclear events downstream of ESR-membrane signaling EML4 and NUDC in mitotic spindle formation
Drugs
Diseases		Anophthalmia and microphthalmia (A/M) Septo-optic dysplasia
GWAS		Chronotype ( 30696823) Excessive hairiness ( 29895819) Eyebrow thickness ( 30248107) General risk tolerance (MTAG) ( 30643258) Monobrow ( 27182965) Night sleep phenotypes ( 27126917) Self-reported risk-taking behaviour ( 30181555)	Atrial fibrillation ( 29892015) Eosinophil counts ( 27863252) Erectile dysfunction ( 30583798) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) Urinary sodium excretion ( 31409800)
Interacting Genes		17 interacting genes: AKT1 ALX4 CASP8 CDX1 COP1 FZR1 L3MBTL3 MAPK3 NR5A1 OTUD7B POU2F1 POU5F1 SETD7 SUMO1 UBE2D3 UBR5 XPO1	77 interacting genes: ABL1 ADAR AGFG1 AHR ANP32A ANP32B APC ATF2 BECN1 BIRC5 BRCA2 CCND1 CDC25A CDCA4 CDKN1B CHEK1 CHORDC1 CIITA CRK DDX3X DESI1 DR1 E2F4 E2F5 EIF5A ERF FBXO7 FOXO4 HDAC3 HNF4A HSPA9 HSPB1 IRF5 KIF17 MAPK6 NF2 NMD3 NPM1 NUCB1 NUCB2 NUP153 NUP214 NUP50 NUP62 NXF3 NXT1 ORC1 PHAX PHB PKIA RAD51 RAN RANBP2 RANBP3 RCC1 RCN2 RGS14 RIC8A RPS6KB1 SERPINB1 SERTAD2 SIRT2 SMAD1 SMARCB1 SMURF1 SMURF2 SNUPN SOX2 STAT1 STRADA SUMO1 TERF2IP TERT TOP2A TOP2B TP53 TP73
Entrez ID		6657	7514
HPRD ID		08921	03975
Ensembl ID		ENSG00000181449	ENSG00000082898
Uniprot IDs		A0A0U3FYV6 P48431	B3KWD0 O14980
PDB IDs		1O4X 2LE4	1W9C 2L1L 3GB8 4BSM 4BSN 5DIS
Enriched GO Terms of Interacting Partners?
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