SOX2 and OTUD7B

Number of citations of the paper that reports this interaction (PubMedID 30405104)
2

Data Source:
BioGRID (pull down)

		SOX2	OTUD7B
Description		SRY-box transcription factor 2	OTU deubiquitinase 7B
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Nuclear Transcription Factor Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding MiRNA Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	DNA Binding Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Zinc Ion Binding Thiol-dependent Ubiquitinyl Hydrolase Activity K63-linked Polyubiquitin Modification-dependent Protein Binding Lys48-specific Deubiquitinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Eye Development Endodermal Cell Fate Specification Chromatin Organization Regulation Of Transcription, DNA-templated Cell Cycle Arrest Response To Wounding Anatomical Structure Morphogenesis Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Glial Cell Fate Commitment Pituitary Gland Development Adenohypophysis Development Positive Regulation Of Cell-cell Adhesion Cell Differentiation Forebrain Development Somatic Stem Cell Population Maintenance Tissue Regeneration Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAPK Cascade Cell Fate Commitment Positive Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development Negative Regulation Of Epithelial Cell Proliferation Response To Growth Factor Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Population Maintenance	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Adaptive Immune Response Mucosal Immune Response Protein Deubiquitination Negative Regulation Of Interleukin-8 Production Protein K11-linked Deubiquitination Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Localization To Nucleus
Pathways		POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Deactivation of the beta-catenin transactivating complex Transcriptional regulation of pluripotent stem cells Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by MECP2	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ovarian tumor domain proteases
Drugs
Diseases		Anophthalmia and microphthalmia (A/M) Septo-optic dysplasia
GWAS		Chronotype ( 30696823) Excessive hairiness ( 29895819) Eyebrow thickness ( 30248107) General risk tolerance (MTAG) ( 30643258) Monobrow ( 27182965) Night sleep phenotypes ( 27126917) Self-reported risk-taking behaviour ( 30181555)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Breast cancer ( 29059683) Heel bone mineral density ( 30598549) Height ( 25282103) Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656)
Interacting Genes		17 interacting genes: AKT1 ALX4 CASP8 CDX1 COP1 FZR1 L3MBTL3 MAPK3 NR5A1 OTUD7B POU2F1 POU5F1 SETD7 SUMO1 UBE2D3 UBR5 XPO1	9 interacting genes: AURKA CCNB1 CDC20 FZR1 SOX2 TRAF6 UBC UBE2S ZDHHC17
Entrez ID		6657	56957
HPRD ID		08921	10313
Ensembl ID		ENSG00000181449	ENSG00000264522
Uniprot IDs		A0A0U3FYV6 P48431	Q6GQQ9
PDB IDs		1O4X 2LE4	5LRU 5LRV 5LRW
Enriched GO Terms of Interacting Partners?
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