SNTB1 and SCN4A

Number of citations of the paper that reports this interaction (PubMedID 9412493)
97

Data Source:
HPRD (in vitro)

		SNTB1	SCN4A
Description		syntrophin beta 1	sodium voltage-gated channel alpha subunit 4
Image		No pdb structure
GO Annotations	Cellular Component	Intracellular Cytoplasm Cytoskeleton Focal Adhesion Dystrophin-associated Glycoprotein Complex Protein-containing Complex Sarcolemma Synapse	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Plasma Membrane Axon
	Molecular Function	Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding PDZ Domain Binding	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Cation Channel Activity Protein Binding
	Biological Process	Muscle Contraction	Sodium Ion Transport Muscle Contraction Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Membrane Depolarization During Action Potential Regulation Of Skeletal Muscle Contraction By Action Potential
Pathways			Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs			Lidocaine Valproic Acid Diclofenac Propofol Zonisamide Flecainide Brivaracetam Chloroxylenol Parachlorophenol
Diseases			Hyperkalemic periodic paralysis (HyperPP) Potassium-aggravated myotonias (PAMs), including: Myotonia fluctuans; Myotonia permanens; Acetazolamide responsive myotonia Hypokalemic periodic paralysis (HypoPP) Paramyotonia congenita (PMC) Congenital myasthenic syndrome
GWAS		C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cerebrospinal T-tau levels ( 28247064) Eye morphology ( 29921221) HDL cholesterol levels ( 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29083408) JT interval (sulfonylurea treatment interaction) ( 27958378) Myopia (pathological) ( 23406873) Myopia (severe) ( 23933737) Periodontitis (CDC/AAP) ( 24024966) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Thalamus volume ( 31530798)	Height ( 28552196 31562340)
Interacting Genes		12 interacting genes: ABCA1 ADGRB1 ADRA1D DGKZ DMD DTNA KCNJ12 MAPK12 RPS6KA1 SCN4A SCN5A UTRN	10 interacting genes: CALM1 DLG1 DLG2 DLG3 ERBIN PATJ SLC9A3R1 SNTA1 SNTB1 SNTB2
Entrez ID		6641	6329
HPRD ID		02490	04912
Ensembl ID		ENSG00000172164	ENSG00000007314
Uniprot IDs		Q13884	P35499
PDB IDs			6AGF 6MBA 6MC9
Enriched GO Terms of Interacting Partners?
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