SCN4A and SNTB1

Number of citations of the paper that reports this interaction (PubMedID 9412493)
97

Data Source:
HPRD (in vitro)

		SCN4A	SNTB1
Description		sodium voltage-gated channel alpha subunit 4	syntrophin beta 1
Image			No pdb structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Plasma Membrane Axon	Intracellular Cytoplasm Cytoskeleton Focal Adhesion Dystrophin-associated Glycoprotein Complex Protein-containing Complex Sarcolemma Synapse
	Molecular Function	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Cation Channel Activity Protein Binding	Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding PDZ Domain Binding
	Biological Process	Sodium Ion Transport Muscle Contraction Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Membrane Depolarization During Action Potential Regulation Of Skeletal Muscle Contraction By Action Potential	Muscle Contraction
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs		Lidocaine Valproic Acid Diclofenac Propofol Zonisamide Flecainide Brivaracetam Chloroxylenol Parachlorophenol
Diseases		Hyperkalemic periodic paralysis (HyperPP) Potassium-aggravated myotonias (PAMs), including: Myotonia fluctuans; Myotonia permanens; Acetazolamide responsive myotonia Hypokalemic periodic paralysis (HypoPP) Paramyotonia congenita (PMC) Congenital myasthenic syndrome
GWAS		Height ( 28552196 31562340)	C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cerebrospinal T-tau levels ( 28247064) Eye morphology ( 29921221) HDL cholesterol levels ( 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29083408) JT interval (sulfonylurea treatment interaction) ( 27958378) Myopia (pathological) ( 23406873) Myopia (severe) ( 23933737) Periodontitis (CDC/AAP) ( 24024966) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Thalamus volume ( 31530798)
Interacting Genes		10 interacting genes: CALM1 DLG1 DLG2 DLG3 ERBIN PATJ SLC9A3R1 SNTA1 SNTB1 SNTB2	12 interacting genes: ABCA1 ADGRB1 ADRA1D DGKZ DMD DTNA KCNJ12 MAPK12 RPS6KA1 SCN4A SCN5A UTRN
Entrez ID		6329	6641
HPRD ID		04912	02490
Ensembl ID		ENSG00000007314	ENSG00000172164
Uniprot IDs		P35499	Q13884
PDB IDs		6AGF 6MBA 6MC9
Enriched GO Terms of Interacting Partners?
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