SMPD1 and BEX3

Number of citations of the paper that reports this interaction (PubMedID 11238738)
12

Data Source:
HPRD (in vivo)

		SMPD1	BEX3
Description		sphingomyelin phosphodiesterase 1	brain expressed X-linked 3
Image
GO Annotations	Cellular Component	Extracellular Space Lysosome Endosome Plasma Membrane Lamellar Body Lysosomal Lumen Extracellular Exosome	Nucleus Cytosol
	Molecular Function	Sphingomyelin Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding Hydrolase Activity, Acting On Glycosyl Bonds Acid Sphingomyelin Phosphodiesterase Activity	Nerve Growth Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Identical Protein Binding Metal Ion Binding
	Biological Process	Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Glycosphingolipid Metabolic Process Signal Transduction Nervous System Development Cholesterol Metabolic Process Termination Of Signal Transduction Positive Regulation Of Protein Dephosphorylation Response To Cocaine Positive Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Ceramide Biosynthetic Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Multicellular Organism Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Pathways		Glycosphingolipid metabolism	NADE modulates death signalling
Drugs		Amlodipine Chlorpromazine Desipramine
Diseases		Niemann-Pick disease (NPD), including;; Niemann-Pick disease, type A; Niemann-Pick disease, type B
GWAS		Blood protein levels ( 30072576) Diisocyanate-induced asthma ( 25918132) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		6 interacting genes: ANXA4 ANXA7 ASAH1 BEX3 DUSP23 NR1H2	29 interacting genes: AIMP2 AKAP8L CACYBP CCDC116 CCDC85B CTNNBL1 DIABLO EMILIN1 FSD2 GOLGA8EP GOLGA8F MIF MNAT1 NECAB2 NGFR NTRK3 PTPN13 SIVA1 SMPD1 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TSC1 USHBP1 VTA1 YWHAE
Entrez ID		6609	27018
HPRD ID		06353	02291
Ensembl ID		ENSG00000166311	ENSG00000166681
Uniprot IDs		E9LUE8 E9LUE9 P17405 Q59EN6 Q8IUN0	Q00994
PDB IDs		5I81 5I85 5I8R 5JG8	1SA6
Enriched GO Terms of Interacting Partners?
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