BMPR1A and TGFBRAP1

Number of citations of the paper that reports this interaction (PubMedID 11278302)
14

Data Source:
HPRD (in vivo)

		BMPR1A	TGFBRAP1
Description		bone morphogenetic protein receptor type 1A	transforming growth factor beta receptor associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Caveola External Side Of Plasma Membrane Integral Component Of Membrane Dendrite Neuronal Cell Body Receptor Complex HFE-transferrin Receptor Complex	Early Endosome Membrane CORVET Complex Intracellular Membrane-bounded Organelle
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding BMP Receptor Activity	Transforming Growth Factor Beta Receptor Binding Protein Binding SMAD Binding
	Biological Process	In Utero Embryonic Development Mesoderm Formation Somitogenesis Mullerian Duct Regression Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Conduction System Development Mitral Valve Morphogenesis Tricuspid Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Ventricular Compact Myocardium Morphogenesis Endocardial Cushion Formation Protein Phosphorylation Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Ectoderm Development Dorsal/ventral Axis Specification Dorsal/ventral Pattern Formation Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Neural Crest Cell Development Negative Regulation Of Smooth Muscle Cell Migration Stem Cell Population Maintenance Pituitary Gland Development Neural Plate Mediolateral Regionalization Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Hindlimb Morphogenesis Dorsal Aorta Morphogenesis Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Structural Organization Lateral Mesoderm Development Regulation Of Lateral Mesodermal Cell Fate Specification Mesendoderm Development Embryonic Organ Development Developmental Growth Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Roof Of Mouth Development Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of SMAD Protein Signal Transduction Heart Formation BMP Signaling Pathway Involved In Heart Development Pharyngeal Arch Artery Morphogenesis Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Cardiac Ventricle Development Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Fibrous Ring Of Heart Morphogenesis Regulation Of Neural Crest Cell Differentiation Regulation Of Cellular Senescence	Regulation Of Transcription, DNA-templated Intracellular Protein Transport Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Endosome To Lysosome Transport Vesicle-mediated Transport Endosomal Vesicle Fusion
Pathways		Signaling by BMP
Drugs
Diseases		Hereditary mixed polyposis syndrome Juvenile polyposis syndrome
GWAS			AIDS ( 19754311) Body mass index ( 26426971) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Menarche (age at onset) ( 27182965) Obesity-related traits ( 23251661) Preeclampsia ( 23551011)
Interacting Genes		25 interacting genes: ACVR1 BAMBI BMP2 BMP4 BMP5 BMP6 BMP7 BMPR1B BMPR2 FKBP1A FKBP1B GDF5 GDF6 GDF9 HOXC8 NEDD4 NEDD4L OTUB1 SF3B4 SMAD1 TAB1 TDGF1 TGFBRAP1 USP15 ZMYND11	10 interacting genes: ACVR1B ACVR2B ACVRL1 ALOX5 BMPR1A EIF4E2 SMAD2 SMAD4 TGFBR1 TGFBR2
Entrez ID		657	9392
HPRD ID		03192	06948
Ensembl ID		ENSG00000107779	ENSG00000135966
Uniprot IDs		P36894	Q8WUH2
PDB IDs		1ES7 1REW 2GOO 2H62 2H64 2K3G 2QJ9 2QJA 2QJB 3NH7 3QB4
Enriched GO Terms of Interacting Partners?
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