TGFBRAP1 and ALOX5

Number of citations of the paper that reports this interaction (PubMedID 10051563)
18

Data Source:
HPRD (in vivo)

		TGFBRAP1	ALOX5
Description		transforming growth factor beta receptor associated protein 1	arachidonate 5-lipoxygenase
Image		No pdb structure
GO Annotations	Cellular Component	Early Endosome Membrane CORVET Complex Intracellular Membrane-bounded Organelle	Extracellular Region Extracellular Space Nuclear Envelope Nuclear Envelope Lumen Nucleoplasm Cytosol Plasma Membrane Nuclear Matrix Nuclear Membrane Secretory Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Transforming Growth Factor Beta Receptor Binding Protein Binding SMAD Binding	Arachidonate 5-lipoxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen
	Biological Process	Regulation Of Transcription, DNA-templated Intracellular Protein Transport Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Endosome To Lysosome Transport Vesicle-mediated Transport Endosomal Vesicle Fusion	Leukocyte Chemotaxis Involved In Inflammatory Response Leukotriene Production Involved In Inflammatory Response Leukotriene Metabolic Process Cytokine-mediated Signaling Pathway Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Lipid Oxidation Interleukin-18-mediated Signaling Pathway Long-chain Fatty Acid Biosynthetic Process Neutrophil Degranulation Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Hepoxilin Biosynthetic Process Oxidation-reduction Process Lipoxin Biosynthetic Process
Pathways			Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of Lipoxins (LX) Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Interleukin-18 signaling Biosynthesis of D-series resolvins Biosynthesis of maresins Biosynthesis of E-series 18(S)-resolvins Biosynthesis of aspirin-triggered D-series resolvins Biosynthesis of E-series 18(R)-resolvins Biosynthesis of DPAn-3-derived protectins and resolvins Biosynthesis of DPAn-3-derived maresins Biosynthesis of DPAn-3-derived 13-series resolvins Biosynthesis of electrophilic Ï‰-3 PUFA oxo-derivatives
Drugs			Vitamin E Masoprocol Aminosalicylic Acid Mesalazine Montelukast Diclofenac Diethylcarbamazine Zileuton Sulfasalazine Meclofenamic acid Balsalazide Minocycline Hyperforin Resveratrol Licofelone MLN-977 Diacerein Rhein
Diseases
GWAS		AIDS ( 19754311) Body mass index ( 26426971) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Menarche (age at onset) ( 27182965) Obesity-related traits ( 23251661) Preeclampsia ( 23551011)	Cholesterol, total ( 24097068) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978) Total cholesterol levels ( 28334899)
Interacting Genes		10 interacting genes: ACVR1B ACVR2B ACVRL1 ALOX5 BMPR1A EIF4E2 SMAD2 SMAD4 TGFBR1 TGFBR2	19 interacting genes: ACTB ALOX5AP ALPL APP CEP57L1 CEP63 COTL1 DICER1 GRB2 HHIPL2 LTC4S MAD1L1 MAPKAPK2 MEOX1 MTDH NUTM1 REL SYCE1 TGFBRAP1
Entrez ID		9392	240
HPRD ID		06948	01065
Ensembl ID		ENSG00000135966	ENSG00000012779
Uniprot IDs		Q8WUH2	P09917
PDB IDs			2ABV 3O8Y 3V92 3V98 3V99
Enriched GO Terms of Interacting Partners?
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