SHMT2 and CLEC2D

Number of citations of the paper that reports this interaction (PubMedID 27107012)
28

Data Source:
BioGRID (two hybrid)

		SHMT2	CLEC2D
Description		serine hydroxymethyltransferase 2	C-type lectin domain family 2 member D
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Microtubule Cytoskeleton Mitochondrial Nucleoid Extracellular Exosome BRISC Complex	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Chromatin Binding Glycine Hydroxymethyltransferase Activity Protein Binding Zinc Ion Binding L-allo-threonine Aldolase Activity Amino Acid Binding Pyridoxal Phosphate Binding Identical Protein Binding Cobalt Ion Binding Serine Binding	Transmembrane Signaling Receptor Activity Carbohydrate Binding
	Biological Process	Regulation Of Oxidative Phosphorylation Glycine Metabolic Process L-serine Metabolic Process L-serine Biosynthetic Process L-serine Catabolic Process One-carbon Metabolic Process Positive Regulation Of Cell Proliferation Glycine Biosynthetic Process From Serine Response To Type I Interferon Tetrahydrofolate Interconversion Tetrahydrofolate Metabolic Process Folic Acid Metabolic Process Protein Tetramerization Protein Homotetramerization Regulation Of Mitochondrial Translation Protein K63-linked Deubiquitination Regulation Of Aerobic Respiration Cellular Response To Tetrahydrofolate	Cell Surface Receptor Signaling Pathway Regulation Of Immune Response
Pathways		Metabolism of folate and pterines	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		Pyridoxal Phosphate Tetrahydrofolic acid Glycine
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 25056061 29483656)	HDL cholesterol levels x short total sleep time interaction (1df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Multiple sclerosis ( 31604244)
Interacting Genes		12 interacting genes: APP ARL6IP1 CLEC2D CMTM5 CREB3 CSNK2B ESR1 FBXO7 KASH5 MAL2 NDRG1 PPARD	2 interacting genes: KLRB1 SHMT2
Entrez ID		6472	29121
HPRD ID		00717	16134
Ensembl ID		ENSG00000182199	ENSG00000069493
Uniprot IDs		A0A024RB99 B4DJQ3 B4DLV4 P34897 Q5BJF5 Q5HYG8 V9HW06	Q9UHP7 W8JXM2
PDB IDs		4PVF 5V7I 5X3V 6DK3 6H3C 6QVG 6QVL 6R8F	4QKG 4QKH 4QKI 4QKJ 4WCO 5MGT
Enriched GO Terms of Interacting Partners?
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