CLEC2D and SHMT2

Number of citations of the paper that reports this interaction (PubMedID 27107012)
28

Data Source:
BioGRID (two hybrid)

		CLEC2D	SHMT2
Description		C-type lectin domain family 2 member D	serine hydroxymethyltransferase 2
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Microtubule Cytoskeleton Mitochondrial Nucleoid Extracellular Exosome BRISC Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Carbohydrate Binding	Chromatin Binding Glycine Hydroxymethyltransferase Activity Protein Binding Zinc Ion Binding L-allo-threonine Aldolase Activity Amino Acid Binding Pyridoxal Phosphate Binding Identical Protein Binding Cobalt Ion Binding Serine Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Regulation Of Immune Response	Regulation Of Oxidative Phosphorylation Glycine Metabolic Process L-serine Metabolic Process L-serine Biosynthetic Process L-serine Catabolic Process One-carbon Metabolic Process Positive Regulation Of Cell Proliferation Glycine Biosynthetic Process From Serine Response To Type I Interferon Tetrahydrofolate Interconversion Tetrahydrofolate Metabolic Process Folic Acid Metabolic Process Protein Tetramerization Protein Homotetramerization Regulation Of Mitochondrial Translation Protein K63-linked Deubiquitination Regulation Of Aerobic Respiration Cellular Response To Tetrahydrofolate
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Metabolism of folate and pterines
Drugs			Pyridoxal Phosphate Tetrahydrofolic acid Glycine
Diseases
GWAS		HDL cholesterol levels x short total sleep time interaction (1df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Multiple sclerosis ( 31604244)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 25056061 29483656)
Interacting Genes		2 interacting genes: KLRB1 SHMT2	12 interacting genes: APP ARL6IP1 CLEC2D CMTM5 CREB3 CSNK2B ESR1 FBXO7 KASH5 MAL2 NDRG1 PPARD
Entrez ID		29121	6472
HPRD ID		16134	00717
Ensembl ID		ENSG00000069493	ENSG00000182199
Uniprot IDs		Q9UHP7 W8JXM2	A0A024RB99 B4DJQ3 B4DLV4 P34897 Q5BJF5 Q5HYG8 V9HW06
PDB IDs		4QKG 4QKH 4QKI 4QKJ 4WCO 5MGT	4PVF 5V7I 5X3V 6DK3 6H3C 6QVG 6QVL 6R8F
Enriched GO Terms of Interacting Partners?
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