SHMT1 and DEDD

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		SHMT1	DEDD
Description		serine hydroxymethyltransferase 1	death effector domain containing
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Extracellular Exosome	Nucleolus Cytoplasm
	Molecular Function	Translation Repressor Activity, MRNA Regulatory Element Binding Glycine Hydroxymethyltransferase Activity Protein Binding Zinc Ion Binding L-allo-threonine Aldolase Activity Amino Acid Binding Pyridoxal Phosphate Binding Identical Protein Binding Protein Homodimerization Activity MRNA 5'-UTR Binding Cobalt Ion Binding Serine Binding	DNA Binding Protein Binding
	Biological Process	DTMP Biosynthetic Process Glycine Metabolic Process L-serine Metabolic Process L-serine Catabolic Process One-carbon Metabolic Process Purine Nucleobase Biosynthetic Process Negative Regulation Of Translation Glycine Biosynthetic Process From Serine Tetrahydrofolate Interconversion Carnitine Biosynthetic Process Tetrahydrofolate Metabolic Process Folic Acid Metabolic Process Protein Homotetramerization Cellular Response To Tetrahydrofolate Cellular Response To Leukemia Inhibitory Factor	Spermatogenesis Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Apoptotic Process
Pathways		Metabolism of folate and pterines Carnitine synthesis
Drugs		Pyridoxal Phosphate Tetrahydrofolic acid Glycine Mimosine Triglu-5-Formyl-Tetrahydrofolate 5-Hydroxymethylene-6-Hydrofolic Acid N-Pyridoxyl-Glycine-5-Monophosphate
Diseases
GWAS		Blood protein levels ( 30072576) Change in neurofilament light levels ( 31295725) Multiple sclerosis ( 27386562)
Interacting Genes		8 interacting genes: CSNK2B DEDD DLEU1 FBXO7 MAPK9 PIM1 PRSS23 SULT1A3	16 interacting genes: APLP2 APP BATF2 CASP10 CASP3 CASP8 CFLAR DEDD2 FADD GTF3C1 GTF3C3 HOXD4 KRT18 KRT8 SHMT1 SMAD3
Entrez ID		6470	9191
HPRD ID		01643	06022
Ensembl ID		ENSG00000176974	ENSG00000158796
Uniprot IDs		P34896	B1AQP5 O75618
PDB IDs		1BJ4 6FL5
Enriched GO Terms of Interacting Partners?
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