SHMT1 and DLEU1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SHMT1	DLEU1
Description		serine hydroxymethyltransferase 1	deleted in lymphocytic leukemia 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	Translation Repressor Activity, MRNA Regulatory Element Binding Glycine Hydroxymethyltransferase Activity Protein Binding Zinc Ion Binding L-allo-threonine Aldolase Activity Amino Acid Binding Pyridoxal Phosphate Binding Identical Protein Binding Protein Homodimerization Activity MRNA 5'-UTR Binding Cobalt Ion Binding Serine Binding
	Biological Process	DTMP Biosynthetic Process Glycine Metabolic Process L-serine Metabolic Process L-serine Catabolic Process One-carbon Metabolic Process Purine Nucleobase Biosynthetic Process Negative Regulation Of Translation Glycine Biosynthetic Process From Serine Tetrahydrofolate Interconversion Carnitine Biosynthetic Process Tetrahydrofolate Metabolic Process Folic Acid Metabolic Process Protein Homotetramerization Cellular Response To Tetrahydrofolate Cellular Response To Leukemia Inhibitory Factor
Pathways		Metabolism of folate and pterines Carnitine synthesis
Drugs		Pyridoxal Phosphate Tetrahydrofolic acid Glycine Mimosine Triglu-5-Formyl-Tetrahydrofolate 5-Hydroxymethylene-6-Hydrofolic Acid N-Pyridoxyl-Glycine-5-Monophosphate
Diseases
GWAS		Blood protein levels ( 30072576) Change in neurofilament light levels ( 31295725) Multiple sclerosis ( 27386562)	Adiponectin levels ( 26299439) Adiponectin levels (BMI-adjusted) ( 26299439) Aluminium levels ( 26025379) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Blood urea nitrogen levels ( 31152163) Circulating odd-numbered chain saturated fatty acid levels (C19:0) ( 29738550) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) FEV1 ( 30804560) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 31562340 31217584) Hematocrit ( 29403010) Hemoglobin ( 29403010) Hip circumference adjusted for BMI ( 28552196) Lipoprotein (a) levels ( 30108283) Lung function (FVC) ( 30804560) Multiple sclerosis ( 31604244 21833088 27386562) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Plasma anti-thyroid peroxidase levels ( 29678681) Primary biliary cholangitis ( 26394269) Prostate-specific antigen levels ( 28139693) Triglycerides ( 30275531) Tumor necrosis factor alpha levels ( 31217265) Type 2 diabetes ( 30054458 30297969) Urinary albumin-to-creatinine ratio ( 31630189) Urinary magnesium excretion ( 31993563) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196) Weight ( 28552196)
Interacting Genes		8 interacting genes: CSNK2B DEDD DLEU1 FBXO7 MAPK9 PIM1 PRSS23 SULT1A3	20 interacting genes: ABCD4 ABCF3 ARL8B CCDC90B CEP126 COPS6 EEF1A1 EEF1G GDF9 GOPC KAT5 MED31 PSMA1 SETDB1 SHMT1 TLE1 TP53 TUBB4B UBR1 UTP14A
Entrez ID		6470	10301
HPRD ID		01643	16150
Ensembl ID		ENSG00000176974	ENSG00000176124
Uniprot IDs		P34896
PDB IDs		1BJ4 6FL5
Enriched GO Terms of Interacting Partners?
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