IKZF4 and CHD4

Number of citations of the paper that reports this interaction (PubMedID 12015313)
24

Data Source:
HPRD (in vivo)

		IKZF4	CHD4
Description		IKAROS family zinc finger 4	chromodomain helicase DNA binding protein 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Protein-containing Complex	Nuclear Chromatin Nucleoplasm Cytoplasm Centrosome Membrane NuRD Complex Protein-containing Complex
	Molecular Function	DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Repressing Transcription Factor Binding DNA Binding DNA Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Nucleosomal DNA Binding Histone Deacetylase Binding
	Biological Process	Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein Homooligomerization	Regulation Of Transcription By RNA Polymerase II DNA Duplex Unwinding ATP-dependent Chromatin Remodeling Regulation Of Signal Transduction By P53 Class Mediator
Pathways			HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription NGF-stimulated transcription
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Alopecia areata ( 20596022 25608926) Anorexia nervosa ( 28494655) Asthma ( 21804548 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Cognitive ability (MTAG) ( 29186694) Cognitive function ( 25644384) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil percentage of granulocytes ( 27863252) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Type 1 diabetes ( 21829393 25751624 18198356) Vitiligo ( 27723757 22561518)	Heel bone mineral density ( 30598549) Myopia (pathological) ( 23049088)
Interacting Genes		12 interacting genes: CHD4 FHL2 FOXP3 HDAC2 IKZF1 IKZF2 IKZF3 IKZF5 NFKBIA NRG1 SIN3A SIN3B	19 interacting genes: ATM ATR CSNK2A1 EP300 H3-4 H3C1 HDAC1 IKZF4 MBD3L2 MTNR1A PSTPIP1 RNF8 RORC SMARCA4 SUMO2 TRIM27 TWIST1 UBE2I XRN1
Entrez ID		64375	1108
HPRD ID		05874	04472
Ensembl ID		ENSG00000123411	ENSG00000111642
Uniprot IDs		Q9H2S9	F5GWX5 Q14839
PDB IDs		2MA7	1MM2 1MM3 2EE1 2L5U 2L75 2N5N 4O9I 6BGG
Enriched GO Terms of Interacting Partners?
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