CHD4 and MBD3L2

Number of citations of the paper that reports this interaction (PubMedID 15701600)
14

Data Source:
BioGRID (pull down)

		CHD4	MBD3L2
Description		chromodomain helicase DNA binding protein 4	methyl-CpG binding domain protein 3 like 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleoplasm Cytoplasm Centrosome Membrane NuRD Complex Protein-containing Complex	Nucleus
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Repressing Transcription Factor Binding DNA Binding DNA Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Nucleosomal DNA Binding Histone Deacetylase Binding	Methyl-CpG Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II DNA Duplex Unwinding ATP-dependent Chromatin Remodeling Regulation Of Signal Transduction By P53 Class Mediator	Negative Regulation Of Transcription By RNA Polymerase II Methylation-dependent Chromatin Silencing
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription NGF-stimulated transcription
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Myopia (pathological) ( 23049088)
Interacting Genes		19 interacting genes: ATM ATR CSNK2A1 EP300 H3-4 H3C1 HDAC1 IKZF4 MBD3L2 MTNR1A PSTPIP1 RNF8 RORC SMARCA4 SUMO2 TRIM27 TWIST1 UBE2I XRN1	10 interacting genes: CHD4 HDAC1 HDAC2 MBD2 MBD3 MTA1 MTA2 POLD3 RBBP4 RBBP7
Entrez ID		1108	125997
HPRD ID		04472	12139
Ensembl ID		ENSG00000111642	ENSG00000230522
Uniprot IDs		F5GWX5 Q14839	Q8NHZ7
PDB IDs		1MM2 1MM3 2EE1 2L5U 2L75 2N5N 4O9I 6BGG
Enriched GO Terms of Interacting Partners?
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