CCL8 and ACKR4

Number of citations of the paper that reports this interaction (PubMedID 10734104)
12

Data Source:
HPRD (in vitro)

		CCL8	ACKR4
Description		C-C motif chemokine ligand 8	atypical chemokine receptor 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cell	Cell Early Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Recycling Endosome
	Molecular Function	Protein Kinase Activity Protein Binding Chemokine Activity Heparin Binding Phospholipase Activator Activity CCR Chemokine Receptor Binding	Chemokine Receptor Activity Scavenger Receptor Activity Protein Binding C-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding
	Biological Process	Monocyte Chemotaxis Positive Regulation Of Leukocyte Migration Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Negative Regulation By Host Of Viral Genome Replication Eosinophil Chemotaxis Lymphocyte Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Leukocyte Proliferation Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor	Endocytosis Chemotaxis Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways			Chemokine receptors bind chemokines
Drugs		Pidolic Acid
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Crohn's disease ( 22412388)	Blood protein levels ( 28240269) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		9 interacting genes: ACKR1 ACKR2 ACKR4 CCR1 CCR3 CCR5 MMP3 SDF2 VCAN	11 interacting genes: CCL11 CCL13 CCL19 CCL2 CCL21 CCL25 CCL5 CCL7 CCL8 CDK2 CXCL13
Entrez ID		6355	51554
HPRD ID		03791	07298
Ensembl ID		ENSG00000108700	ENSG00000129048
Uniprot IDs		P80075	Q9NPB9
PDB IDs		1ESR
Enriched GO Terms of Interacting Partners?
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