SCN5A and SNTB1

Number of citations of the paper that reports this interaction (PubMedID 9412493)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		SCN5A	SNTB1
Description		sodium voltage-gated channel alpha subunit 5	syntrophin beta 1
Image			No pdb structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Nucleoplasm Nucleolus Endoplasmic Reticulum Plasma Membrane Caveola Cell Surface Intercalated Disc Integral Component Of Membrane Lateral Plasma Membrane Z Disc T-tubule Sarcolemma Perinuclear Region Of Cytoplasm	Intracellular Cytoplasm Cytoskeleton Focal Adhesion Dystrophin-associated Glycoprotein Complex Protein-containing Complex Sarcolemma Synapse
	Molecular Function	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Cation Channel Activity Protein Binding Calmodulin Binding Fibroblast Growth Factor Binding Enzyme Binding Protein Kinase Binding Protein Domain Specific Binding Ankyrin Binding Ubiquitin Protein Ligase Binding Ion Channel Binding Nitric-oxide Synthase Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Sodium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Sodium Channel Activity Involved In Bundle Of His Cell Action Potential Voltage-gated Sodium Channel Activity Involved In Purkinje Myocyte Action Potential Voltage-gated Sodium Channel Activity Involved In SA Node Cell Action Potential Scaffold Protein Binding	Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding PDZ Domain Binding
	Biological Process	Regulation Of Heart Rate Cardiac Ventricle Development Brainstem Development Sodium Ion Transport Positive Regulation Of Sodium Ion Transport Response To Denervation Involved In Regulation Of Muscle Adaptation Neuronal Action Potential Telencephalon Development Cerebellum Development Sodium Ion Transmembrane Transport Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Action Potential Positive Regulation Of Epithelial Cell Proliferation Membrane Depolarization Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Cardiac Conduction Cellular Response To Calcium Ion Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential AV Node Cell Action Potential Bundle Of His Cell Action Potential Membrane Depolarization During AV Node Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Membrane Depolarization During Purkinje Myocyte Cell Action Potential Membrane Depolarization During Bundle Of His Cell Action Potential AV Node Cell To Bundle Of His Cell Communication Regulation Of Heart Rate By Cardiac Conduction Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transmembrane Transport	Muscle Contraction
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs		Indecainide Ranolazine Phenytoin Disopyramide Lidocaine Valproic Acid Mexiletine Hexylcaine Cinchocaine Mephenytoin Carbamazepine Verapamil Moricizine Riluzole Prilocaine Ethotoin Oxcarbazepine Benzonatate Cocaine Quinidine Zonisamide Procainamide Tocainide Propafenone Flecainide Encainide Fosphenytoin Quinidine barbiturate Ajmaline Aprindine Brivaracetam Vernakalant
Diseases		Familial idiopathic ventricular fibrillation Sick sinus syndrome (SSS); Sinus node dysfunction Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS) Brugada syndrome (BRS) Atrial fibrillation
GWAS		Atrial fibrillation ( 30061737 29892015) Brugada syndrome ( 23872634) Electrocardiographic conduction measures ( 23463857 19389651) Electrocardiographic traits ( 20062063) Global electrical heterogeneity phenotypes ( 29622589) P wave duration ( 28794112 24850809) PR interval ( 29127183 30046033 20062060 25035420 31217584 23139255 21347284) PR segment ( 24850809) QRS duration ( 27577874 31251759 25035420 31217584 21076409) QT interval ( 29213071 24952745 19305408 19305409) Resting heart rate ( 27798624) Supraventricular ectopy ( 29618737) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149)	C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cerebrospinal T-tau levels ( 28247064) Eye morphology ( 29921221) HDL cholesterol levels ( 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29083408) JT interval (sulfonylurea treatment interaction) ( 27958378) Myopia (pathological) ( 23406873) Myopia (severe) ( 23933737) Periodontitis (CDC/AAP) ( 24024966) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Thalamus volume ( 31530798)
Interacting Genes		18 interacting genes: CALM1 CBL CDK2 CRYAB DLG1 DLG2 DLG3 DLG4 NEDD4 NEDD4L PATJ RGS2 RGS3 SNTA1 SNTB1 SNTB2 SNTG2 WWP2	12 interacting genes: ABCA1 ADGRB1 ADRA1D DGKZ DMD DTNA KCNJ12 MAPK12 RPS6KA1 SCN4A SCN5A UTRN
Entrez ID		6331	6641
HPRD ID		02543	02490
Ensembl ID		ENSG00000183873	ENSG00000172164
Uniprot IDs		A0A0A0MT39 E9PG18 E9PHB6 H9KVD2 K4DIA1 Q14524 Q86V90	Q13884
PDB IDs		2KBI 2L53 4DCK 4DJC 4JQ0 4OVN 5DBR 6MUD
Enriched GO Terms of Interacting Partners?
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