RPL3 and SIK1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		RPL3	SIK1
Description		ribosomal protein L3	salt inducible kinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Focal Adhesion Cytosolic Large Ribosomal Subunit Protein-containing Complex Synapse Extracellular Exosome	Nucleus Cytoplasm
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding 5S RRNA Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding CAMP Response Element Binding Protein Binding Protein Kinase Binding 14-3-3 Protein Binding
	Biological Process	Ribosomal Large Subunit Assembly Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription Cellular Response To Interleukin-4	Regulation Of Sodium Ion Transport Protein Phosphorylation Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Myotube Differentiation Negative Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of CREB Transcription Factor Activity Intracellular Signal Transduction Entrainment Of Circadian Clock By Photoperiod Regulation Of Cell Differentiation Negative Regulation Of Gluconeogenesis Protein Autophosphorylation Rhythmic Process Cardiac Muscle Cell Differentiation Positive Regulation Of Anoikis
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Circadian Clock
Drugs		Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Omacetaxine mepesuccinate Anisomycin Puromycin Xanthinol	Dabrafenib
Diseases
GWAS		Crohn's disease ( 28067908) Factor VIII levels ( 30586737) Inflammatory bowel disease ( 28067908) Primary biliary cholangitis ( 28425483) Primary biliary cirrhosis ( 22961000) Ulcerative colitis ( 28067908) vWF levels ( 30586737)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Alzheimer disease and age of onset ( 26830138) Blond vs. brown/black hair color ( 30531825) Diastolic blood pressure ( 28135244 27841878 28739976 27618452) Red vs. brown/black hair color ( 30531825) Systolic blood pressure ( 27841878 28739976 27618452)
Interacting Genes		8 interacting genes: CREBBP MTNR1A NDRG1 NUMB SIK1 STXBP3 SUMO2 TRAF6	13 interacting genes: CRTC2 GINS4 HDAC5 MAPT MCM2 NMNAT1 PRKACA RNF2 RPL3 STK11 SUPT5H VAPA YWHAZ
Entrez ID		6122	150094
HPRD ID		16042	09301
Ensembl ID		ENSG00000100316	ENSG00000142178
Uniprot IDs		B3KS36 P39023 Q96QL0	P57059
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
Enriched GO Terms of Interacting Partners?
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