RIT1 and KLHL12

Number of citations of the paper that reports this interaction (PubMedID 18303015)
29

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		RIT1	KLHL12
Description		Ras like without CAAX 1	kelch like family member 12
Image
GO Annotations	Cellular Component	Plasma Membrane	Golgi Membrane Cytosol COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite Intracellular Membrane-bounded Organelle
	Molecular Function	GTPase Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding	Protein Binding Identical Protein Binding
	Biological Process	Signal Transduction Ras Protein Signal Transduction	Protein Monoubiquitination ER To Golgi Vesicle-mediated Transport Neural Crest Formation Neural Crest Cell Development Wnt Signaling Pathway COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Signalling to p38 via RIT and RIN	Degradation of DVL
Drugs
Diseases
GWAS		Birth weight ( 31043758) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233)
Interacting Genes		15 interacting genes: AFDN AP2A1 CUL3 IFRD1 KLHL12 LRIF1 LRRK2 PTN RALGDS RGL1 RLF SMAD2 SMAD3 SMURF1 SRPK2	46 interacting genes: ARAF ATXN1 BAG6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CRTC3 CUL3 DGCR6 DRD4 DVL2 DVL3 FBXL17 FGD2 FLNA GLYCTK INMT KHSRP KLHL2 KLHL3 LNX1 MED28 MPP1 MRPL10 MTNR1A NDC80 NTAQ1 PDGFRB PEA15 PEF1 PRR13 RIT1 RPP25L SDCBP SEC31A SNX20 SYNE4 TAOK2 TBC1D10C TTBK2 UBE2I VEGFB VTA1 ZBP1
Entrez ID		6016	59349
HPRD ID		10195	13925
Ensembl ID		ENSG00000143622	ENSG00000117153
Uniprot IDs		Q92963	Q53G59 Q9H7R2
PDB IDs		4KLZ	2VPJ
Enriched GO Terms of Interacting Partners?
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