RIT1 and AP2A1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		RIT1	AP2A1
Description		Ras like without CAAX 1	adaptor related protein complex 2 subunit alpha 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane	Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane AP-2 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Filopodium Tip Endolysosome Membrane Clathrin-coated Endocytic Vesicle
	Molecular Function	GTPase Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding	Protein Binding Protein C-terminus Binding Protein Kinase Binding Clathrin Adaptor Activity Protein-containing Complex Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Signal Transduction Ras Protein Signal Transduction	Intracellular Protein Transport Golgi To Endosome Transport Endocytosis Positive Regulation Of Neuron Projection Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Low-density Lipoprotein Particle Receptor Catabolic Process Low-density Lipoprotein Particle Clearance Ephrin Receptor Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Defense Response To Virus By Virus Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Organization Clathrin-dependent Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process
Pathways		Signalling to p38 via RIT and RIN	Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Trafficking of GluR2-containing AMPA receptors Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance
Drugs
Diseases
GWAS		Birth weight ( 31043758) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233)
Interacting Genes		15 interacting genes: AFDN AP2A1 CUL3 IFRD1 KLHL12 LRIF1 LRRK2 PTN RALGDS RGL1 RLF SMAD2 SMAD3 SMURF1 SRPK2	26 interacting genes: AP2S1 BIN1 CLINT1 DEK DNM2 DPYSL2 EHD1 EPN1 EPS15 GHR HIP1 NAGPA NUMB PICALM PIN1 RAB11FIP2 RIT1 SHBG SHC1 SMAD9 SNAP29 SYNJ1 SYT3 SYT7 TOE1 UBC
Entrez ID		6016	160
HPRD ID		10195	03016
Ensembl ID		ENSG00000143622	ENSG00000196961
Uniprot IDs		Q92963	O95782
PDB IDs		4KLZ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?