RHEB and FKBP8

Number of citations of the paper that reports this interaction (PubMedID 17991864)
134

Data Source:
BioGRID (pull down, two hybrid)

		RHEB	FKBP8
Description		Ras homolog, mTORC1 binding	FKBP prolyl isomerase 8
Image
GO Annotations	Cellular Component	Golgi Membrane Spliceosomal Complex Lysosomal Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Postsynaptic Density Membrane Extracellular Exosome	Mitochondrion Endoplasmic Reticulum Cytosol Membrane Integral Component Of Endoplasmic Reticulum Membrane Mitochondrial Membrane Protein-containing Complex
	Molecular Function	Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Identical Protein Binding Protein Binding Involved In Protein Folding Metal Ion Binding Disordered Domain Specific Binding
	Biological Process	Cell Cycle Arrest Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Positive Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Cold-induced Thermogenesis Regulation Of Type B Pancreatic Cell Development	Protein Peptidyl-prolyl Isomerization Cell Fate Specification Negative Regulation Of Protein Phosphorylation Protein Folding Apoptotic Process Smoothened Signaling Pathway Viral Process Dorsal/ventral Neural Tube Patterning Positive Regulation Of BMP Signaling Pathway Multicellular Organism Growth Intracellular Signal Transduction Camera-type Eye Development Negative Regulation Of Apoptotic Process
Pathways		Macroautophagy mTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	Ub-specific processing proteases
Drugs		Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611) Metabolite levels ( 23823483)	Plasma parathyroid hormone levels ( 30134803) Urinary potassium excretion ( 31409800)
Interacting Genes		26 interacting genes: A2M APOE ARIH2 ATM ATR BNIP3 BNIP3L BRAF CREB3 ECSIT FKBP8 HTT MTOR NCAM1 PDE6D PLD1 PSEN1 PSEN2 RABAC1 RAF1 RNF152 RPS6KB1 RPTOR TSC1 TSC2 USP4	17 interacting genes: ANKMY2 ARHGEF5 ATP13A2 BCL2 BCL2L1 BNIPL CLCN1 EGFR EGLN1 MAPK14 MTOR PPP3CA PSMC1 PSMD2 RHEB TERF1 VHL
Entrez ID		6009	23770
HPRD ID		03188	05327
Ensembl ID		ENSG00000106615	ENSG00000105701
Uniprot IDs		A0A090N900 Q15382	A0A024R7P2 B2R8G6 Q14318
PDB IDs		1XTQ 1XTR 1XTS 3SEA 3T5G 5YXH 6BCU 6BSX 6BT0	2AWG 2D9F 2F2D 2MF9 3EY6 5MGX
Enriched GO Terms of Interacting Partners?
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