RAC2 and ARFIP2

Number of citations of the paper that reports this interaction (PubMedID 11346801)
88

Data Source:
HPRD (in vitro)

		RAC2	ARFIP2
Description		Rac family small GTPase 2	ADP ribosylation factor interacting protein 2
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GO Annotations	Cellular Component	Cell Nuclear Envelope Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium Phagocytic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle Extracellular Exosome	Ruffle Cytoplasm Cytosol Plasma Membrane Cell Cortex Trans-Golgi Network Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Kinase Regulator Activity Protein Kinase Binding	Protein Binding GTP Binding Phospholipid Binding Protein Domain Specific Binding GTP-dependent Protein Binding Identical Protein Binding Cadherin Binding Rac GTPase Binding Phosphatidylinositol-4-phosphate Binding Membrane Curvature Sensor Activity
	Biological Process	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Motor Neuron Axon Guidance Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Lamellipodium Assembly Regulation Of Cell-substrate Adhesion Rac Protein Signal Transduction Cell Projection Assembly Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of T Cell Proliferation Regulation Of Mast Cell Degranulation Engulfment Of Apoptotic Cell Bone Resorption Cell Redox Homeostasis Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling Regulation Of Respiratory Burst Regulation Of Mast Cell Chemotaxis Lymphocyte Aggregation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Positive Regulation Of Protein Targeting To Mitochondrion	Intracellular Protein Transport Autophagy Small GTPase Mediated Signal Transduction Lamellipodium Assembly Actin Cytoskeleton Organization Ruffle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		GPVI-mediated activation cascade ROS and RNS production in phagocytes PIP3 activates AKT signaling Rho GTPase cycle Constitutive Signaling by Aberrant PI3K in Cancer PCP/CE pathway RHO GTPases Activate NADPH Oxidases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Retrograde transport at the Trans-Golgi-Network
Drugs		Dextromethorphan
Diseases		Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS		Graves' disease ( 23612905) Longevity ( 20834067) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Type 1 diabetes ( 25751624)
Interacting Genes		23 interacting genes: ACTB ADAM22 AFG3L2 AGAP2 ARFIP2 ARHGDIA ARHGDIB BRD2 CDC42 CHGB CHPF CUL1 DEF6 DOCK2 GDI1 ICMT NCF2 NOS2 NOXA1 PAK2 RTKN SMAD1 SMAD4	26 interacting genes: AGTRAP AKT1 APP ARF1 ARF3 ARF5 ARF6 ARL1 CDKN2A CEP63 DTNBP1 HAUS1 HGS ING5 ITGB3BP ITSN1 KRT15 LY6D MAL2 RAC1 RAC2 SNX1 SOCS2 STAT3 TRIM54 USHBP1
Entrez ID		5880	23647
HPRD ID		03628	07209
Ensembl ID		ENSG00000128340	ENSG00000132254
Uniprot IDs		A0A024R1P2 P15153 V9H0H7	A0A087X1E4 B4DUZ3 B4DXH2 P53365
PDB IDs		1DS6 2W2T 2W2V 2W2X	1I49 1I4D 1I4L 1I4T 4DCN
Enriched GO Terms of Interacting Partners?
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