NECTIN1 and NECTIN4

Number of citations of the paper that reports this interaction (PubMedID 12011057)
41

Data Source:
HPRD (in vitro)

		NECTIN1	NECTIN4
Description		nectin cell adhesion molecule 1	nectin cell adhesion molecule 4
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Adherens Junction Membrane Integral Component Of Membrane Dendrite Growth Cone Membrane Intracellular Membrane-bounded Organelle Apical Junction Complex Cell-cell Contact Zone Hippocampal Mossy Fiber To CA3 Synapse Integral Component Of Presynaptic Active Zone Membrane	Plasma Membrane Adherens Junction Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Virus Receptor Activity Protein Binding Coreceptor Activity Carbohydrate Binding Signaling Receptor Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Virion Binding Cell Adhesion Molecule Binding	Virus Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Lens Morphogenesis In Camera-type Eye Desmosome Organization Iron Ion Transport Immune Response Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Axon Guidance Virion Attachment To Host Cell Adherens Junction Organization Viral Entry Into Host Cell Regulation Of Synapse Assembly Retina Development In Camera-type Eye Enamel Mineralization Cell-cell Adhesion Protein Localization To Cell Junction	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Adherens Junction Organization Viral Entry Into Host Cell
Pathways		Adherens junctions interactions Nectin/Necl trans heterodimerization	Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs
Diseases		Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate	Ectodermal dysplasia-syndactyly syndrome (EDSS)
GWAS
Interacting Genes		10 interacting genes: AFDN CBL FGFR1 FGFR2 FGFR3 NECTIN3 NECTIN4 PARD3 PRNP PVR	5 interacting genes: AFDN NECTIN1 NECTIN2 PICK1 TIGIT
Entrez ID		5818	81607
HPRD ID		07200	17934
Ensembl ID		ENSG00000110400	ENSG00000143217
Uniprot IDs		Q15223	K4PZ75 Q96NY8
PDB IDs		3ALP 3SKU 3U82 3U83 4FMF 4MYW	4FRW 4GJT 4JJH
Enriched GO Terms of Interacting Partners?
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