NECTIN1 and NECTIN3

Number of citations of the paper that reports this interaction (PubMedID 12011057)
41

Data Source:
HPRD (in vitro)

		NECTIN1	NECTIN3
Description		nectin cell adhesion molecule 1	nectin cell adhesion molecule 3
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Adherens Junction Membrane Integral Component Of Membrane Dendrite Growth Cone Membrane Intracellular Membrane-bounded Organelle Apical Junction Complex Cell-cell Contact Zone Hippocampal Mossy Fiber To CA3 Synapse Integral Component Of Presynaptic Active Zone Membrane	Plasma Membrane Cell-cell Junction Adherens Junction Axon Dendrite Apical Junction Complex Cell-cell Contact Zone Hippocampal Mossy Fiber To CA3 Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Virus Receptor Activity Protein Binding Coreceptor Activity Carbohydrate Binding Signaling Receptor Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Virion Binding Cell Adhesion Molecule Binding	Protein Binding Signaling Receptor Activity Protein Homodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Lens Morphogenesis In Camera-type Eye Desmosome Organization Iron Ion Transport Immune Response Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Axon Guidance Virion Attachment To Host Cell Adherens Junction Organization Viral Entry Into Host Cell Regulation Of Synapse Assembly Retina Development In Camera-type Eye Enamel Mineralization Cell-cell Adhesion Protein Localization To Cell Junction	Lens Morphogenesis In Camera-type Eye Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Spermatid Development Fertilization Adherens Junction Organization Retina Morphogenesis In Camera-type Eye Establishment Of Protein Localization To Plasma Membrane Protein Localization To Cell Junction
Pathways		Adherens junctions interactions Nectin/Necl trans heterodimerization	Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs
Diseases		Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
GWAS			Feeling hurt ( 29500382)
Interacting Genes		10 interacting genes: AFDN CBL FGFR1 FGFR2 FGFR3 NECTIN3 NECTIN4 PARD3 PRNP PVR	13 interacting genes: AFDN KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 NECTIN1 NECTIN2 NOTCH2NLA PARD3 PVR RGS20 TIGIT
Entrez ID		5818	25945
HPRD ID		07200	08454
Ensembl ID		ENSG00000110400	ENSG00000177707
Uniprot IDs		Q15223	Q9NQS3
PDB IDs		3ALP 3SKU 3U82 3U83 4FMF 4MYW	4FOM
Enriched GO Terms of Interacting Partners?
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