PVR and WNK1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		PVR	WNK1
Description		PVR cell adhesion molecule	WNK lysine deficient protein kinase 1
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Integral Component Of Membrane	Cytoplasm Cytosol Membrane
	Molecular Function	Virus Receptor Activity Protein Binding Signaling Receptor Activity Protein Homodimerization Activity Cell Adhesion Molecule Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity Protein Kinase Binding Phosphatase Binding Protein Kinase Activator Activity
	Biological Process	Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Adherens Junction Organization Susceptibility To Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Viral Entry Into Host Cell Regulation Of Immune Response Susceptibility To T Cell Mediated Cytotoxicity	Regulation Of Sodium Ion Transport Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Ion Transport Negative Regulation Of Sodium Ion Transport Positive Regulation Of T Cell Chemotaxis Negative Regulation Of Phosphatase Activity Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Trans-phosphorylation Activation Of Protein Kinase Activity Positive Regulation Of Ion Transmembrane Transporter Activity Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of GTPase Activity Intracellular Signal Transduction Chemokine (C-C Motif) Ligand 21 Signaling Pathway Neuron Development Regulation Of Cellular Process Ion Homeostasis T Cell Receptor Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Lymphocyte Migration Into Lymph Node Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Potassium Ion Import Cellular Response To Chemokine Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Nectin/Necl trans heterodimerization	Stimuli-sensing channels
Drugs		Sphingosine Myristic acid
Diseases			Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS		Alzheimer's disease ( 24755620) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Mean platelet volume ( 27863252) Multiple sclerosis ( 21833088) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376)	Blood protein levels ( 29875488) Body mass index ( 25673413 29273807) Eosinophil counts ( 27863252) Eosinophil percentage of white cells ( 27863252) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Manganese levels ( 26025379) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Squamous cell lung carcinoma ( 28604730) Stroke ( 19369658)
Interacting Genes		25 interacting genes: AP1M2 CD226 CD96 DMPK DYNLT1 DYNLT3 GMEB2 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 NECTIN1 NECTIN2 NECTIN3 NOTCH2NLA PLA2G3 PLAT PSG11 PSG9 PSMD8 SLC22A4 SLC30A2 TIGIT VTN WNK1	35 interacting genes: ADRB2 AKT1 ARAF ATXN1 BAG3 CLTC COPS5 CSDE1 E2F3 FHL3 FLNC GLIS2 KLHL2 KLHL3 MAP2K1 MAP3K2 MAP3K3 MT-ATP8 PFKP PRKAR1A PRKAR1B PVR RANBP9 SLC9A1 SYT2 TNRC6A TSC22D1 UBE2I UPF2 WNK2 YWHAE YWHAG YWHAZ ZNF106 ZYX
Entrez ID		5817	65125
HPRD ID		01434	05570
Ensembl ID		ENSG00000073008	ENSG00000060237
Uniprot IDs		A0A0A0MSA9 A0A0C4DG49 A8K4I1 P15151	A5D8Z4 F5GWT4 Q9H4A3
PDB IDs		1DGI 1NN8 3EPC 3EPD 3EPF 3J8F 3J9F 3UDW 3URO 4FQP 6ARQ 6ISC 6O3O	4PWN 5TF9 5WDY 5WE8 6FBK
Enriched GO Terms of Interacting Partners?
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