WNK1 and BAG3

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		WNK1	BAG3
Description		WNK lysine deficient protein kinase 1	BAG cochaperone 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Stress Fiber Cell Nucleus Cytoplasm Cytosol Plasma Membrane Aggresome Z Disc Neuron Projection Chaperone Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity Protein Kinase Binding Phosphatase Binding Protein Kinase Activator Activity	Adenyl-nucleotide Exchange Factor Activity Protein Binding Protein-containing Complex Binding Cadherin Binding Dynein Intermediate Chain Binding Chaperone Binding
	Biological Process	Regulation Of Sodium Ion Transport Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Ion Transport Negative Regulation Of Sodium Ion Transport Positive Regulation Of T Cell Chemotaxis Negative Regulation Of Phosphatase Activity Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Trans-phosphorylation Activation Of Protein Kinase Activity Positive Regulation Of Ion Transmembrane Transporter Activity Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of GTPase Activity Intracellular Signal Transduction Chemokine (C-C Motif) Ligand 21 Signaling Pathway Neuron Development Regulation Of Cellular Process Ion Homeostasis T Cell Receptor Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Lymphocyte Migration Into Lymph Node Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Potassium Ion Import Cellular Response To Chemokine Positive Regulation Of Sodium Ion Transmembrane Transporter Activity	Autophagosome Assembly Protein Folding Brain Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Striated Muscle Cell Apoptotic Process Spinal Cord Development Cellular Response To Heat Cellular Response To Unfolded Protein Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Muscle Cell Cellular Homeostasis Positive Regulation Of Protein Export From Nucleus Regulation Of Catalytic Activity Protein Stabilization Chaperone-mediated Autophagy Aggresome Assembly Cellular Response To Mechanical Stimulus Chaperone-mediated Protein Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Transport Along Microtubule Regulation Of Cellular Response To Heat Negative Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Aggrephagy
Pathways		Stimuli-sensing channels	Regulation of HSF1-mediated heat shock response
Drugs
Diseases		Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS		Blood protein levels ( 29875488) Body mass index ( 25673413 29273807) Eosinophil counts ( 27863252) Eosinophil percentage of white cells ( 27863252) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Manganese levels ( 26025379) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Squamous cell lung carcinoma ( 28604730) Stroke ( 19369658)	Diastolic blood pressure ( 27841878) Heart failure ( 31919418) Idiopathic dilated cardiomyopathy ( 21459883) Parkinson's disease ( 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		35 interacting genes: ADRB2 AKT1 ARAF ATXN1 BAG3 CLTC COPS5 CSDE1 E2F3 FHL3 FLNC GLIS2 KLHL2 KLHL3 MAP2K1 MAP3K2 MAP3K3 MT-ATP8 PFKP PRKAR1A PRKAR1B PVR RANBP9 SLC9A1 SYT2 TNRC6A TSC22D1 UBE2I UPF2 WNK2 YWHAE YWHAG YWHAZ ZNF106 ZYX	25 interacting genes: ACD ARRDC3 BCL2 CRYAB DAZAP2 DVL2 DYNLT1 FAM189A2 FBXO7 HSPA1A HSPA8 HSPB1 HSPB8 LITAF LRRK1 LRRK2 MAGED1 PDE9A PLCG1 POT1 SF3B4 SRPK2 TINF2 TNK2 WNK1
Entrez ID		65125	9531
HPRD ID		05570	04860
Ensembl ID		ENSG00000060237	ENSG00000151929
Uniprot IDs		A5D8Z4 F5GWT4 Q9H4A3	O95817
PDB IDs		4PWN 5TF9 5WDY 5WE8 6FBK
Enriched GO Terms of Interacting Partners?
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