MARK4 and HPS6

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		MARK4	HPS6
Description		microtubule affinity regulating kinase 4	HPS6 biogenesis of lysosomal organelles complex 2 subunit 3
Image			No pdb structure
GO Annotations	Cellular Component	Gamma-tubulin Complex Cytoplasm Centrosome Microtubule Organizing Center Cytosol Microtubule Cytoskeleton Dendrite Midbody Ciliary Basal Body Neuron Projection	Lysosomal Membrane Endoplasmic Reticulum Membrane BLOC-2 Complex Early Endosome Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Gamma-tubulin Binding Ubiquitin Binding Tau Protein Binding Tau-protein Kinase Activity	Protein Binding Rab GTPase Binding GTP-dependent Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Protein Phosphorylation Cell Cycle Nervous System Development Intracellular Signal Transduction Positive Regulation Of Programmed Cell Death Cilium Organization Positive Regulation Of Cilium Assembly Regulation Of Centrosome Cycle Cell Division Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Protein Localization To Centrosome	Organelle Organization Blood Coagulation Melanocyte Differentiation Lysosome Localization Protein Localization To Membrane
Pathways		Anchoring of the basal body to the plasma membrane
Drugs
Diseases			Hermansky-Pudlak syndrome (HPS)
GWAS		Advanced age-related macular degeneration ( 26691988) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Eosinophil counts ( 27863252) Granulocyte count ( 27863252) Hematocrit ( 27863252) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Parental longevity (father's attained age) ( 29227965) Platelet count ( 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)	Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435)
Interacting Genes		28 interacting genes: CDC42 HGS HNRNPK HPS6 KHDRBS3 KRT31 KRT40 MAP2 MAP4 MAPT MTUS2 NEDD4 NOTCH2NLA ODF2 PARD6A PNMA1 PRKCG PRKCI PRNP PTBP1 RPTOR STK11 TUBA4A TUBB TUBG1 YWHAB YWHAH YWHAZ	9 interacting genes: CREB1 EP300 HPS5 MARK4 MNAT1 OSGEP PIK3CB PUM3 TTC19
Entrez ID		57787	79803
HPRD ID		09402	08471
Ensembl ID		ENSG00000007047	ENSG00000166189
Uniprot IDs		Q96L34	Q86YV9
PDB IDs		5ES1
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?