MIB1 and CEP131

Number of citations of the paper that reports this interaction (PubMedID 24121310)
48

Data Source:
BioGRID (affinity chromatography technology, pull down)

		MIB1	CEP131
Description		mindbomb E3 ubiquitin protein ligase 1	centrosomal protein 131
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Postsynaptic Density Cytoplasmic Vesicle	Acrosomal Vesicle Centrosome Cytosol Microtubule Cytoskeleton Centriolar Satellite Ciliary Transition Zone Ciliary Basal Body Intracellular Membrane-bounded Organelle Intercellular Bridge
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding	Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding
	Biological Process	Blood Vessel Development In Utero Embryonic Development Somitogenesis Neural Tube Formation Heart Looping Ubiquitin-dependent Protein Catabolic Process Endocytosis Notch Signaling Pathway Protein Ubiquitination Negative Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis	G2/M Transition Of Mitotic Cell Cycle Multicellular Organism Development Spermatogenesis Positive Regulation Of Cell Proliferation Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Centrosome Duplication Cell Differentiation Intraciliary Transport Involved In Cilium Assembly Cilium Assembly Protein Localization To Centrosome Positive Regulation Of Intracellular Protein Transport Ciliary Basal Body-plasma Membrane Docking
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Severe progression in rheumatoid arthritis ( 29065906)	Frontotemporal dementia ( 26154020)
Interacting Genes		20 interacting genes: AZI2 BLM CABLES1 CEP131 CHST9 DAB2 DAPK1 EPB41L4A GABARAP JAG1 RMC1 SNX5 TBK1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2N UBE2U UBE2W	4 interacting genes: MAPKAPK2 MIB1 YWHAE YWHAZ
Entrez ID		57534	22994
HPRD ID		06660	16532
Ensembl ID		ENSG00000101752	ENSG00000141577
Uniprot IDs		Q86YT6	I3L2J8 Q9UPN4
PDB IDs		4TSE 4XI6 4XI7 4XIB
Enriched GO Terms of Interacting Partners?
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