MAP3K7CL and GPS2

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
HPRD (two hybrid)

		MAP3K7CL	GPS2
Description		MAP3K7 C-terminal like	G protein pathway suppressor 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Nucleus Nucleoplasm Mitochondrion Cytosol Transcriptional Repressor Complex
	Molecular Function	Protein Binding	Transcription Coactivator Activity Transcription Corepressor Activity GTPase Inhibitor Activity Protein Binding Cyclin Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Inactivation Of MAPK Activity JNK Cascade Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Viral Process Regulation Of Lipid Metabolic Process B Cell Differentiation Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of GTPase Activity Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Negative Regulation Of B Cell Receptor Signaling Pathway Response To Mitochondrial Depolarisation Negative Regulation Of Protein K63-linked Ubiquitination
Pathways			PPARA activates gene expression HDACs deacetylate histones Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Estimated glomerular filtration rate after 1 year in renal transplantation (recipient effect) ( 30920136) Gamma glutamyl transferase levels ( 29403010) Ventricular ectopy ( 29618737)
Interacting Genes		6 interacting genes: AK8 CISH GPS2 KRT31 REL TAB3	24 interacting genes: ATF4 C19orf57 CCNA1 CHD3 CNOT2 ELOB EP300 GOLGA2 HDAC1 HDAC3 KRT31 MAP3K7CL NCOR1 NR0B2 PBK PRMT6 RBPMS SESTD1 SETDB1 SPDL1 TBL1X TBL1XR1 TFIP11 TP53
Entrez ID		56911	2874
HPRD ID		10764	11878
Ensembl ID		ENSG00000156265	ENSG00000132522
Uniprot IDs		B0EVZ6 B0EVZ7 B0EVZ8 B4DFW0 P57077	Q13227
PDB IDs			2L5G
Enriched GO Terms of Interacting Partners?
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