PPM1B and RYK

Number of citations of the paper that reports this interaction (PubMedID 28065597)
26

Data Source:
BioGRID (two hybrid)

		PPM1B	RYK
Description		protein phosphatase, Mg2+/Mn2+ dependent 1B	receptor like tyrosine kinase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytosol Membrane	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Receptor Complex
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Phosphatase Activity Magnesium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Manganese Ion Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Frizzled Binding Protein Binding ATP Binding Wnt-protein Binding Wnt-activated Receptor Activity Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway
	Biological Process	Protein Dephosphorylation N-terminal Protein Myristoylation Negative Regulation Of Interferon-beta Production Peptidyl-threonine Dephosphorylation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Defense Response To Virus Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of NIK/NF-kappaB Signaling	Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Axonogenesis Axon Guidance Synapse Assembly Wnt Signaling Pathway Peptidyl-tyrosine Phosphorylation Neurogenesis Corpus Callosum Development Neuron Differentiation Neuron Projection Development Cell Proliferation In Midbrain Positive Regulation Of Kinase Activity Non-canonical Wnt Signaling Pathway Chemorepulsion Of Dopaminergic Neuron Axon Positive Regulation Of MAPK Cascade Skeletal System Morphogenesis Negative Regulation Of Axon Extension Involved In Axon Guidance Canonical Wnt Signaling Pathway Commissural Neuron Axon Guidance Planar Cell Polarity Pathway Involved In Axon Guidance Midbrain Dopaminergic Neuron Differentiation Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation
Pathways		ISG15 antiviral mechanism	TCF dependent signaling in response to WNT PCP/CE pathway
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Chronotype ( 30696823) Estimated glomerular filtration rate ( 31152163) Height ( 23563607 31562340) Metabolite levels ( 23823483) Morning person ( 30696823) Number of sexual partners ( 30643258) Risk-taking tendency (4-domain principal component model) ( 30643258)	Cadmium levels ( 26025379) Diastolic blood pressure ( 27841878 30578418) Height ( 31562340) Systolic blood pressure ( 28135244 27841878)
Interacting Genes		19 interacting genes: AATK CDK2 CDK6 ECHS1 EGFR ERBB3 ERBB4 IKBKB IKBKG KDR MAP3K7 MSN PPARG PTK7 ROR1 ROR2 RYK SIRPA VAV2	8 interacting genes: EPHB2 EPHB3 FZD8 PPM1B PPP3CA PTPRR WNT1 WNT3A
Entrez ID		5495	6259
HPRD ID		04796	02751
Ensembl ID		ENSG00000138032	ENSG00000163785
Uniprot IDs		O75688	P34925 Q59FQ5 Q8WTZ8
PDB IDs		2P8E
Enriched GO Terms of Interacting Partners?
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